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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >
Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema
| Title: | Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema |
| Authors: | Fujimori, Motoshi Browse this author | | Nakamura, Satoko Browse this author | | Hasegawa, Kiminori Browse this author | | Ikeno, Kunihiro Browse this author | | Ichikawa, Shota Browse this author | | Sutherland, Kenneth Browse this author →KAKEN DB | | Kamishima, Tamotsu Browse this author →KAKEN DB |
| Issue Date: | Aug-2017 |
| Publisher: | British Institute of Radiology |
| Journal Title: | British journal of radiology |
| Volume: | 90 |
| Issue: | 1077 |
| Start Page: | 20170167 |
| Publisher DOI: | 10.1259/bjr.20170167 |
| PMID: | 28707530 |
| Abstract: | Objective: To quantify wrist cartilage using contrast MRI and compare with the extent of adjacent synovitis and bone marrow edema (BME) in patients with rheumatoid arthritis (RA). Methods: 18 patients with RA underwent post-contrast fat-suppressed T-1 weighted coronal imaging. Cartilage area at the centre of the scaphoid-capitate and radius-scaphoid joints was measured by in-house developed software. We defined cartilage as the pixels with signal intensity between two thresholds (lower: 0.4, 0.5 and 0.6 times the muscle signal, upper: 0.9, 1.0, 1.1, 1.2 and 1.3 times the muscle signal). We investigated the association of cartilage loss with synovitis and BME score derived from RA MRI scoring system. Results: Cartilage area was correlated with BME score when thresholds were adequately set with lower threshold at 0.6 times the muscle signal and upper threshold at 1.2 times the muscle signal for both SC (r(s)=-0.469, p < 0.05) and RS (r(s)= -0.486,p < 0.05) joints, while it showed no significant correlation with synovitis score at any thresholds. Conclusion: Our software can accurately quantify cartilage in the wrist and BME associated with cartilage loss in patients with RA. Advances in knowledge: Our software can quantify cartilage using conventional MR images of the wrist. BME is associated with cartilage loss in RA patients. |
| Rights: | Fujimori, M., Nakamura, S., Hasegawa, K., Ikeno, K., Ichikawa, S., Sutherland, K., Kamishima, T., Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema, British journal of radiology, 2017; 90:20170167. |
| Relation: | http://www.birpublications.org/toc/bjr/current |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71397 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 神島 保
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