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Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71397

Title: Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema
Authors: Fujimori, Motoshi Browse this author
Nakamura, Satoko Browse this author
Hasegawa, Kiminori Browse this author
Ikeno, Kunihiro Browse this author
Ichikawa, Shota Browse this author
Sutherland, Kenneth Browse this author →KAKEN DB
Kamishima, Tamotsu Browse this author →KAKEN DB
Issue Date: Aug-2017
Publisher: British Institute of Radiology
Journal Title: British journal of radiology
Volume: 90
Issue: 1077
Start Page: 20170167
Publisher DOI: 10.1259/bjr.20170167
PMID: 28707530
Abstract: Objective: To quantify wrist cartilage using contrast MRI and compare with the extent of adjacent synovitis and bone marrow edema (BME) in patients with rheumatoid arthritis (RA). Methods: 18 patients with RA underwent post-contrast fat-suppressed T-1 weighted coronal imaging. Cartilage area at the centre of the scaphoid-capitate and radius-scaphoid joints was measured by in-house developed software. We defined cartilage as the pixels with signal intensity between two thresholds (lower: 0.4, 0.5 and 0.6 times the muscle signal, upper: 0.9, 1.0, 1.1, 1.2 and 1.3 times the muscle signal). We investigated the association of cartilage loss with synovitis and BME score derived from RA MRI scoring system. Results: Cartilage area was correlated with BME score when thresholds were adequately set with lower threshold at 0.6 times the muscle signal and upper threshold at 1.2 times the muscle signal for both SC (r(s)=-0.469, p < 0.05) and RS (r(s)= -0.486,p < 0.05) joints, while it showed no significant correlation with synovitis score at any thresholds. Conclusion: Our software can accurately quantify cartilage in the wrist and BME associated with cartilage loss in patients with RA. Advances in knowledge: Our software can quantify cartilage using conventional MR images of the wrist. BME is associated with cartilage loss in RA patients.
Rights: Fujimori, M., Nakamura, S., Hasegawa, K., Ikeno, K., Ichikawa, S., Sutherland, K., Kamishima, T., Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema, British journal of radiology, 2017; 90:20170167.
Relation: http://www.birpublications.org/toc/bjr/current
Type: article
URI: http://hdl.handle.net/2115/71397
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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