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Thrombotic risk stratification by platelet count in patients with antiphospholipid antibodies : a longitudinal study

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Title: Thrombotic risk stratification by platelet count in patients with antiphospholipid antibodies : a longitudinal study
Other Titles: Platelet count and thrombosis in aPL carriers
Authors: Hisada, R.1 Browse this author
Kato, M.2 Browse this author →KAKEN DB
Sugawara, E.3 Browse this author
Fujieda, Y.4 Browse this author
Oku, K.5 Browse this author
Bohgaki, T.6 Browse this author
Amengual, O.7 Browse this author →KAKEN DB
Yasuda, S.8 Browse this author →KAKEN DB
Atsumi, T.9 Browse this author →KAKEN DB
Authors(alt): Hisada, Ryo1
Kato, Masaru2
Sugawara, Eri3
Fujieda, Yuichiro4
Oku, Kenji5
Bohgaki, Toshiyuki6
Amengual, Olga7
Yasuda, Shinsuke8
Atsumi, Tatsuya9
Keywords: antiphospholipid antibodies
antiphospholipid syndrome
platelet count
thrombocytopenia
thrombosis
Issue Date: Sep-2017
Publisher: John Wiley & Sons
Journal Title: Journal of thrombosis and haemostasis
Volume: 15
Issue: 9
Start Page: 1782
End Page: 1787
Publisher DOI: 10.1111/jth.13763
PMID: 28662299
Abstract: Background: Thrombocytopenia is a non-criteria clinical manifestation of antiphospholipid syndrome. However, it remains to be elucidated whether thrombocytopenia increases thrombotic risk in antiphospholipid antibody (aPL) carriers. Objectives: To investigate the impact of platelet count in terms of predicting thrombotic events in aPL carriers, and to stratify the thrombotic risk by combining platelet count and antiphospholipid score (aPL-S), which represents a quantification of aPL varieties and titers. Patients/methods: A single-center, retrospective, longitudinal study comprising 953 consecutive patients who were suspected of having autoimmune disease between January 2002 and December 2006 was performed. Low platelet count was defined as a count of < 150 × 10^3 μL-1 at the time of aPL testing. Results: A negative correlation was observed between aPL-S and platelet count (r = -0.2477). Among aPL-positive patients, those with a low platelet count developed thrombosis more frequently than those without (hazard ratio [HR] 2.95, 95% confidence interval [CI] 1.11-7.88). Among aPL-negative patients, no difference was found in the predictive value of thrombosis regardless of platelet count. Patients with aPLs were further divided into two subgroups according to aPL-S. Among low-aPL-S patients, those with low platelet counts developed thrombosis more frequently than those without (HR 3.44, 95% CI 1.05-11.2). In contrast, high-aPL-S patients developed thrombosis frequently regardless of platelet count. Conclusions: aPL carriers with low platelet counts are at high risk of developing thrombosis. In particular, 'low-aPL-S carriers' may be stratified by platelet count in terms of predicting future thrombotic events.
Rights: This is the peer reviewed version of the following article: Hisada R, Kato M, Sugawara E, Fujieda Y, Oku K, Bohgaki T, Amengual O, Yasuda S, Atsumi T. Thrombotic risk stratification by platelet count in patients with antiphospholipid antibodies: a longitudinal study. J Thromb Haemost 2017; 15: 1782–7, which has been published in final form at https://doi.org/10.1111/jth.13763. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/71409
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久田 諒

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