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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins
| Title: | Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins |
| Authors: | Kato, Eisuke Browse this author →KAKEN DB | | Kushibiki, Natsuka Browse this author | | Inagaki, Yosuke Browse this author | | Kurokawa, Mihoko Browse this author | | Kawabata, Jun Browse this author →KAKEN DB |
| Keywords: | pancreatic -amylase | | type 2 diabetes | | procyanidin | | Astilbe thunbergii |
| Issue Date: | Sep-2017 |
| Publisher: | Taylor & Francis |
| Journal Title: | Bioscience biotechnology and biochemistry |
| Volume: | 81 |
| Issue: | 9 |
| Start Page: | 1699 |
| End Page: | 1705 |
| Publisher DOI: | 10.1080/09168451.2017.1353403 |
| PMID: | 28743229 |
| Abstract: | Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic -amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the -amylase inhibitory component with IC50=1.7g/mL against porcine pancreatic -amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable -amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience biotechnology & biochemistry on 2017 Sep, available online: http://wwww.tandfonline.com/10.1080/09168451.2017.1353403. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/71428 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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