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Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins

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Title: Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins
Authors: Kato, Eisuke Browse this author →KAKEN DB
Kushibiki, Natsuka Browse this author
Inagaki, Yosuke Browse this author
Kurokawa, Mihoko Browse this author
Kawabata, Jun Browse this author →KAKEN DB
Keywords: pancreatic -amylase
type 2 diabetes
procyanidin
Astilbe thunbergii
Issue Date: Sep-2017
Publisher: Taylor & Francis
Journal Title: Bioscience biotechnology and biochemistry
Volume: 81
Issue: 9
Start Page: 1699
End Page: 1705
Publisher DOI: 10.1080/09168451.2017.1353403
PMID: 28743229
Abstract: Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic -amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the -amylase inhibitory component with IC50=1.7g/mL against porcine pancreatic -amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable -amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience biotechnology & biochemistry on 2017 Sep, available online: http://wwww.tandfonline.com/10.1080/09168451.2017.1353403.
Type: article (author version)
URI: http://hdl.handle.net/2115/71428
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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