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Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71524

Title: Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan
Authors: Hiono, Takahiro Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Matsuno, Keita Browse this author →KAKEN DB
Haga, Atsushi Browse this author
Iwata, Ritsuko Browse this author
Nguyen, Lam Thanh Browse this author
Suzuki, Mizuho Browse this author
Kikutani, Yuto Browse this author
Kida, Hiroshi Browse this author →KAKEN DB
Onuma, Manabu Browse this author
Sakoda, Yoshihiro Browse this author →KAKEN DB
Keywords: H5N6
highly pathogenic avian influenza virus
wild bird
Issue Date: 16-Aug-2017
Publisher: John Wiley & Sons
Journal Title: Microbiology and immunology
Volume: 61
Issue: 9
Start Page: 387
End Page: 397
Publisher DOI: 10.1111/1348-0421.12506
PMID: 28815716
Abstract: On 15 November 2016, a black swan that had died in a zoo in Akita prefecture, northern Japan, was strongly suspected to have highly pathogenic avian influenza (HPAI); an HPAI virus (HPAIV) belonging to the H5N6 subtype was isolated from specimens taken from the bird. After the initial report, 230 cases of HPAI caused by H5N6 viruses from wild birds, captive birds, and domestic poultry farms were reported throughout the country during the winter season. In the present study, 66 H5N6 HPAIVs isolated from northern Japan were further characterized. Phylogenetic analysis of the hemagglutinin gene showed that the H5N6 viruses isolated in northern Japan clustered into Group C of Clade 2.3.4.4 together with other isolates collected in Japan, Korea and Taiwan during the winter season of 2016-2017. The antigenicity of the Japanese H5N6 isolate differed slightly from that of HPAIVs isolated previously in Japan and China. The virus exhibited high pathogenicity and a high replication capacity in chickens, whereas virus growth was slightly lower in ducks compared with that of an H5N8 HPAIV isolate collected in Japan in 2014. Comprehensive analyses of Japanese isolates, including those from central, western, and southern Japan, as well as rapid publication of this information are essential for facilitating greater control of HPAIVs.
Rights: This is the peer reviewed version of the following article: Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016–2017 in Northern Japan, which has been published in final form at https://doi.org/10.1111/1348-0421.12506. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/71524
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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