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Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study

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Title: Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study
Authors: Aikawa, Tadao Browse this author →KAKEN DB
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Naya, Masanao Browse this author →KAKEN DB
Ohira, Hiroshi Browse this author
Sugimoto, Ayako Browse this author
Tsujino, Ichizo Browse this author →KAKEN DB
Obara, Masahiko Browse this author
Manabe, Osamu Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: Cardiac sarcoidosis
Cardiac CT
Delayed enhancement
Iterative reconstruction
Issue Date: Oct-2017
Publisher: Springer
Journal Title: European Radiology
Volume: 27
Issue: 10
Start Page: 4054
End Page: 4063
Publisher DOI: 10.1007/s00330-017-4824-x
PMID: 28382537
Abstract: Objectives: To evaluate the diagnostic value of delayed contrast-enhanced computed tomography (DE-CT) for cardiac sarcoidosis (CS) in patients with or without implantable devices, including a quantitative comparison with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). Methods: Twenty-four patients (mean age, 64 ± 9 years; 17 women) with known or suspected CS underwent retrospective electrocardiogram-gated DE-CT at 80 kV with knowledge-based iterative model reconstruction. Fourteen patients without implantable devices also underwent LGE-CMR, while ten with pacemakers or implantable cardioverter-defibrillators did not. The presence of hyperenhanced myocardium was assessed visually and quantitatively using a 5-standard deviation threshold above the mean of remote myocardium. Results: Inter-observer agreement for visual detection of hyperenhanced segments on DE-CT was excellent in patients with implantable devices and in those without (κ = 0.91 and κ = 0.94, respectively). Comparisons of the percent area of hyperenhanced myocardium between DE-CT and LGE-CMR on both per-patient and per-segment analyses showed good correlations (r = 0.96 and r = 0.83, respectively; p < 0.001). The sensitivity and specificity of DE-CT for the diagnosis of CS were 94% and 33%. Conclusions: The extent of hyperenhanced lesion with DE-CT showed good agreement with LGE-CMR results. DE-CT showed high sensitivity for detecting CS and may be useful particularly in patients with contraindications to CMR.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 相川 忠夫

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