|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study
| Title: | Delayed contrast-enhanced computed tomography in patients with known or suspected cardiac sarcoidosis : A feasibility study |
| Authors: | Aikawa, Tadao Browse this author →KAKEN DB | | Oyama-Manabe, Noriko Browse this author →KAKEN DB | | Naya, Masanao Browse this author →KAKEN DB | | Ohira, Hiroshi Browse this author | | Sugimoto, Ayako Browse this author | | Tsujino, Ichizo Browse this author →KAKEN DB | | Obara, Masahiko Browse this author | | Manabe, Osamu Browse this author →KAKEN DB | | Kudo, Kohsuke Browse this author →KAKEN DB | | Tsutsui, Hiroyuki Browse this author →KAKEN DB | | Tamaki, Nagara Browse this author →KAKEN DB |
| Keywords: | Cardiac sarcoidosis | | Cardiac CT | | Delayed enhancement | | Myocardium | | Iterative reconstruction |
| Issue Date: | Oct-2017 |
| Publisher: | Springer |
| Journal Title: | European Radiology |
| Volume: | 27 |
| Issue: | 10 |
| Start Page: | 4054 |
| End Page: | 4063 |
| Publisher DOI: | 10.1007/s00330-017-4824-x |
| PMID: | 28382537 |
| Abstract: | Objectives: To evaluate the diagnostic value of delayed contrast-enhanced computed tomography (DE-CT) for cardiac sarcoidosis (CS) in patients with or without implantable devices, including a quantitative comparison with late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). Methods: Twenty-four patients (mean age, 64 ± 9 years; 17 women) with known or suspected CS underwent retrospective electrocardiogram-gated DE-CT at 80 kV with knowledge-based iterative model reconstruction. Fourteen patients without implantable devices also underwent LGE-CMR, while ten with pacemakers or implantable cardioverter-defibrillators did not. The presence of hyperenhanced myocardium was assessed visually and quantitatively using a 5-standard deviation threshold above the mean of remote myocardium. Results: Inter-observer agreement for visual detection of hyperenhanced segments on DE-CT was excellent in patients with implantable devices and in those without (κ = 0.91 and κ = 0.94, respectively). Comparisons of the percent area of hyperenhanced myocardium between DE-CT and LGE-CMR on both per-patient and per-segment analyses showed good correlations (r = 0.96 and r = 0.83, respectively; p < 0.001). The sensitivity and specificity of DE-CT for the diagnosis of CS were 94% and 33%. Conclusions: The extent of hyperenhanced lesion with DE-CT showed good agreement with LGE-CMR results. DE-CT showed high sensitivity for detecting CS and may be useful particularly in patients with contraindications to CMR. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/71561 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 相川 忠夫
|
