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Cell competition in mammals : novel homeostatic machinery for embryonic development and cancer prevention

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Title: Cell competition in mammals : novel homeostatic machinery for embryonic development and cancer prevention
Authors: Maruyama, Takeshi Browse this author
Fujita, Yasuyuki Browse this author →KAKEN DB
Issue Date: Oct-2017
Publisher: Elsevier
Journal Title: Current opinion in cell biology
Volume: 48
Start Page: 106
End Page: 112
Publisher DOI: 10.1016/j.ceb.2017.06.007
PMID: 28719866
Abstract: In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer). Furthermore, physical force can play a crucial role in the intercellular recognition and elimination of loser cells during cell competition. Further studies are expected to reveal a variety of roles of cell competition in embryonic development and human diseases.
Rights: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/71578
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤田 恭之

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