| Title: | Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health |
| Other Titles: | PFASs and cord blood reproductive hormone levels |
| Authors: | Itoh, Sachiko Browse this author →KAKEN DB |
| Araki, Atsuko Browse this author →KAKEN DB |
| Mitsui, Takahiko Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Goudarzi, Houman Browse this author →KAKEN DB |
| Sasaki, Seiko Browse this author →KAKEN DB |
| Cho, Kazutoshi Browse this author →KAKEN DB |
| Nakazawa, Hiroyuki Browse this author →KAKEN DB |
| Iwasaki, Yusuke Browse this author →KAKEN DB |
| Shinohara, Nobuo Browse this author →KAKEN DB |
| Nonomura, Katsuya Browse this author →KAKEN DB |
| Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Perfluoroalkyl substances |
| Reproductive hormones |
| Cord blood |
| Prenatal exposure |
| Birth cohort |
| Issue Date: | Sep-2016 |
| Publisher: | Elsevier |
| Journal Title: | Environment International |
| Volume: | 94 |
| Start Page: | 51 |
| End Page: | 59 |
| Publisher DOI: | 10.1016/j.envint.2016.05.011 |
| PMID: | 27209000 |
| Abstract: | Background: Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones. Objective: To explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones. Methods: In the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother-infant pairs recruited in 2002-2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography-tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL). Results: The median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels. Conclusions: These results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA. |
| Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/71600 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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