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Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71600

Title: Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health
Other Titles: PFASs and cord blood reproductive hormone levels
Authors: Itoh, Sachiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Mitsui, Takahiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Cho, Kazutoshi Browse this author →KAKEN DB
Nakazawa, Hiroyuki Browse this author →KAKEN DB
Iwasaki, Yusuke Browse this author →KAKEN DB
Shinohara, Nobuo Browse this author →KAKEN DB
Nonomura, Katsuya Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Perfluoroalkyl substances
Reproductive hormones
Cord blood
Prenatal exposure
Birth cohort
Issue Date: Sep-2016
Publisher: Elsevier
Journal Title: Environment International
Volume: 94
Start Page: 51
End Page: 59
Publisher DOI: 10.1016/j.envint.2016.05.011
PMID: 27209000
Abstract: Background: Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones. Objective: To explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones. Methods: In the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother-infant pairs recruited in 2002-2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography-tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL). Results: The median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels. Conclusions: These results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/71600
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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