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Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71614

Title: Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure
Authors: Shinotsuka, Naomi Browse this author
Yamaguchi, Yoshifumi Browse this author
Nakazato, Kenichi Browse this author
Matsumoto, Yudai Browse this author
Mochizuki, Atsushi Browse this author
Miura, Masayuki Browse this author
Keywords: Apoptosis
Caspases
Matrix metalloproteases
Neural tube closure
Live-imaging
Issue Date: 31-Jul-2018
Publisher: BioMed Central
Journal Title: BMC developmental biology
Volume: 18
Start Page: 17
Publisher DOI: 10.1186/s12861-018-0175-3
Abstract: Background: Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ectodermal layer. Apoptosis is widely observed from the beginning of NTC at the neural ridges and is crucial for the proper progression of NTC, but its role after the closure remains less clear. Results: Here, we conducted live-imaging analysis of the mid-hindbrain neuropore (MHNP) closure and revealed unexpected collective behavior of cells surrounding the MHNP. The cells first gathered to the closing point and subsequently relocated as if they were released from the point. Inhibition of caspases or matrix metalloproteases with chemical inhibitors impaired the cell relocation. Conclusions: These lines of evidence suggest that apoptosis-mediated degradation of extracellular matrix might facilitate the final process of neuropore closure.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/71614
Appears in Collections:低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山口 良文

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