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Dynamics and function of ERM proteins during cytokinesis in human cells

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Title: Dynamics and function of ERM proteins during cytokinesis in human cells
Authors: Hiruma, Shota Browse this author
Kamasaki, Tomoko Browse this author
Otomo, Kohei Browse this author
Nemoto, Tomomi Browse this author →KAKEN DB
Uehara, Ryota Browse this author →KAKEN DB
Issue Date: 26-Oct-2017
Journal Title: FEBS Letters
Volume: 591
Issue: 20
Start Page: 3296
End Page: 3309
Publisher DOI: 10.1002/1873-3468.12844
PMID: 28889652
Abstract: The molecular mechanism that governs cytoskeleton-membrane interaction during animal cytokinesis remains elusive. Here, we investigated the dynamics and functions of ERM (Ezrin/Radixin/Moesin) proteins during cytokinesis in human cultured cells. We found that ezrin is recruited to the cleavage furrow through its membrane-associated domain in a cholesterol-dependent but largely Rho-independent manner. While ERMs are dispensable for furrow ingression, they play a pivotal role in contractile activity of the polar cortex. Notably, when anillin and supervillin are codepleted, ERMs increasingly accumulate at the cleavage furrow and substantially contribute to the furrow ingression. These results reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site.
Rights: This is the peer reviewed version of the following article: Shota Hiruma, Tomoko Kamasaki, Kohei Otomo, Tomomi Nemoto and Ryota Uehara, Dynamics and function of ERM proteins during cytokinesis in human cells, FEBS Letters 591(20), 2017, doi: 10.1002/1873-3468.12844, which has been published in final form at . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:創成研究機構 (Creative Research Institution) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 上原 亮太

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