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Tetraploidy-associated centrosome overduplication in mouse early embryos
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Tetraploidy-associated centrosome overduplication in mouse early embryos |
| Authors: | Yaguchi, Kan Browse this author | | Yamamoto, Takahiro Browse this author | | Matsui, Ryo Browse this author | | Shimada, Masaya Browse this author | | Shibanuma, Atsuko Browse this author | | Kamimura, Keiko Browse this author | | Koda, Toshiaki Browse this author | | Uehara, Ryota Browse this author →KAKEN DB |
| Keywords: | Tetraploid | | centrosome | | mouse embryo |
| Issue Date: | 2-Oct-2018 |
| Journal Title: | Communicative & Integrative Biology |
| Volume: | 11 |
| Issue: | 4 |
| Start Page: | e1526605-1 |
| End Page: | e1526605-4 |
| Publisher DOI: | 10.1080/19420889.2018.1526605 |
| Abstract: | Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71776 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 上原 亮太
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