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Tetraploidy-associated centrosome overduplication in mouse early embryos

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Title: Tetraploidy-associated centrosome overduplication in mouse early embryos
Authors: Yaguchi, Kan Browse this author
Yamamoto, Takahiro Browse this author
Matsui, Ryo Browse this author
Shimada, Masaya Browse this author
Shibanuma, Atsuko Browse this author
Kamimura, Keiko Browse this author
Koda, Toshiaki Browse this author
Uehara, Ryota Browse this author →KAKEN DB
Keywords: Tetraploid
mouse embryo
Issue Date: 2-Oct-2018
Journal Title: Communicative & Integrative Biology
Volume: 11
Issue: 4
Start Page: e1526605-1
End Page: e1526605-4
Publisher DOI: 10.1080/19420889.2018.1526605
Abstract: Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems.
Type: article
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 上原 亮太

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