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Tetraploidy-associated centrosome overduplication in mouse early embryos


Communicative & Integrative Biologye1526605_1-4.pdf1.36 MBPDF見る/開く

タイトル: Tetraploidy-associated centrosome overduplication in mouse early embryos
著者: Yaguchi, Kan 著作を一覧する
Yamamoto, Takahiro 著作を一覧する
Matsui, Ryo 著作を一覧する
Shimada, Masaya 著作を一覧する
Shibanuma, Atsuko 著作を一覧する
Kamimura, Keiko 著作を一覧する
Koda, Toshiaki 著作を一覧する
Uehara, Ryota 著作を一覧する
キーワード: Tetraploid
mouse embryo
発行日: 2018年10月 2日
誌名: Communicative & Integrative Biology
開始ページ: e1526605-1
終了ページ: e1526605-4
出版社 DOI: 10.1080/19420889.2018.1526605
抄録: Recently, we observed that tetraploidization of certain types of human cancer cells resulted in upregulation of centrosome duplication cycles and chronic generation of the extra centrosome. Here, we investigated whether tetraploidy-linked upregulation of centrosome duplication also occurs in non-cancer cells using tetraploidized parthenogenetic mouse embryos. Cytokinesis blockage at early embryonic stage before de novo centriole biogenesis provided the unique opportunity in which tetraploidization can be induced without transient doubling of centrosome number. The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraploidy-driven centrosome overduplication in mammalian non-cancer systems.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 上原 亮太


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