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Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis : a clinicopathological study of 10 cases

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Title: Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis : a clinicopathological study of 10 cases
Authors: Nakazato, S.1 Browse this author
Fujita, Y.2 Browse this author
Shinkuma, S.3 Browse this author →KAKEN DB
Nomura, T.4 Browse this author
Shimizu, H.5 Browse this author →KAKEN DB
Authors(alt): Nakazato, Shinichi1
Fujita, Yasuyuki2
Shinkuma, Satoru3
Nomura, Toshifumi4
Shimizu, Hiroshi5
Keywords: eosinophilic annular erythema
figurate
pigmentation
basal melanosis
eosinophils
eosinophilia
corticosteroids
Issue Date: Nov-2017
Publisher: John Wiley & Sons
Journal Title: Journal of the European Academy of Dermatology and Venereology
Volume: 31
Issue: 11
Start Page: 1916
End Page: 1923
Publisher DOI: 10.1111/jdv.14350
PMID: 28543605
Abstract: Background: Eosinophilic annular erythema (EAE) has been proposed as a clinical entity to describe annular skin lesions associated with tissue eosinophilia. However, systematic investigations on the histopathology of EAE have not been performed, and useful histopathological findings for diagnosis of EAE remain unknown. Objective: The aim of this study was to investigate the clinicopathological features of EAE. Methods: We retrospectively studied 10 patients at our hospital during a 5-year span who clinically showed annular or figurate lesions and histopathologically exhibited eosinophilic infiltration in the dermis. Results: Nine of the 10 cases had annular lesions with pigmentation on the interior side. Blood eosinophilia was found in only one patient. Histopathologically, basal melanosis was observed in nine cases. Infiltration of eosinophils was confined to the dermis in nine cases. Patients treated with systemic corticosteroid tended to show less recurrence than those treated with topical corticosteroid. Limitations: The main limitation of our study is the small number of patients. Conclusion: Skin biopsy should be performed when EAE is suspected, even in cases without blood eosinophilia. Basal melanosis and tissue eosinophilia confined to the dermis suggest the diagnosis of EAE. We recommend topical corticosteroids as the initial treatment for EAE.
Rights: This is the peer reviewed version of the following article: Nakazato, S., Fujita, Y., Shinkuma, S., Nomura, T. and Shimizu, H. (2017), Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases. J Eur Acad Dermatol Venereol, 31: 1916-1923., which has been published in final form at https://doi.org/10.1111/jdv.14350. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/71780
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中里 信一

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