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The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71863

Title: The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring
Authors: Yanagiya, Shingo Browse this author
Cho, Kyu Yong Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Nomoto, Hiroshi Browse this author
Kawamoto, Yasuyuki Browse this author
Kawakubo, Kazumichi Browse this author →KAKEN DB
Komatsu, Yoshito Browse this author →KAKEN DB
Mitsuhashi, Tomoko Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: everolimus
hypoglycemia
continuous glucose monitoring
Issue Date: 1-Sep-2018
Publisher: The Japanese Society of Internal Medicine
Journal Title: Internal medicine
Volume: 57
Issue: 17
Start Page: 2527
End Page: 2531
Publisher DOI: 10.2169/internalmedicine.0126-17
Abstract: An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed that her blood glucose levels were maintained without hypoglycemia throughout the day. Furthermore, everolimus reduced the duration of time above the upper limit (>180 mg/dL) along with the standard deviation and mean amplitude of glycemic excursions. This case shows the potential effects of everolimus on hypoglycemia and glycemic control in a patient with inoperable metastatic insulinoma evaluated by CGM.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/71863
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中村 昭伸

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