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Long Non-coding RNA NEAT1 : A Novel Target for Diagnosis and Therapy in Human Tumors
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Long Non-coding RNA NEAT1 : A Novel Target for Diagnosis and Therapy in Human Tumors |
| Authors: | Dong, Peixin Browse this author →KAKEN DB | | Xiong, Ying Browse this author | | Yue, Junming Browse this author | | Hanley, Sharon J. B. Browse this author →KAKEN DB | | Kobayashi, Noriko Browse this author | | Todo, Yukiharu Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | NEAT1 | | nuclear paraspeckle assembly transcript 1 | | long non-coding RNA | | cancer diagnosis | | cancer treatment | | EMT | | microRNA |
| Issue Date: | 15-Oct-2018 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in Genetics |
| Volume: | 9 |
| Start Page: | 471 |
| Publisher DOI: | 10.3389/fgene.2018.00471 |
| Abstract: | The nuclear paraspeckle assembly transcript 1 (NEAT1, a long non-coding RNA) is frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with worse survival in cancer patients. NEAT1 drives tumor initiation and progression by modulating the expression of genes involved in the regulation of tumor cell growth, migration, invasion, metastasis, epithelial-to-mesenchymal transition, stem cell-like phenotype, chemoresistance and radioresistance, indicating the potential for NEAT1 to be a novel diagnostic biomarker and therapeutic target. Mechanistically, NEAT1 functions as a scaffold RNA molecule by interacting with EZH2 (a subunit of the polycomb repressive complex) to influence the expression of downstream effectors of EZH2, it also acts as a microRNA (miRNA) sponge to suppress the interactions between miRNAs and target mRNAs, and affects the expression of miR-129 by promoting the DNA methylation of the miR-129 promoter region. Knockdown of NEAT1 via small interfering RNA or short hairpin RNA inhibits the malignant behavior of tumor cells. In this review, we highlight the latest insights into the expression pattern, biological roles and mechanisms underlying the function and regulation of NEAT1 in tumors, and especially focus on its clinical implication as a new diagnostic biomarker and an attractive therapeutic target for cancers. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71891 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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