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Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers
Title: | Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers |
Authors: | Okabe, Hiroaki Browse this author | Shimizu, Chikara Browse this author →KAKEN DB | Yamamoto, Maiko Browse this author | Kikuchi, Rei Browse this author | Minami, Akiko Browse this author | Chen, Yi-Fan Browse this author | Imai, Hideyuki Browse this author →KAKEN DB | Mizuta, Masahiro Browse this author →KAKEN DB | Chen, Zhen Browse this author | Chiba, Hitoshi Browse this author →KAKEN DB | Hui, Shu-Ping Browse this author →KAKEN DB |
Keywords: | 25-Hydroxy vitamin D-3 | LC/MS/MS | UV-B | monthly variation |
Issue Date: | 10-Sep-2018 |
Publisher: | 日本分析化学会 |
Journal Title: | Analytical sciences |
Volume: | 34 |
Issue: | 9 |
Start Page: | 1043 |
End Page: | 1047 |
Publisher DOI: | 10.2116/analsci.18P193 |
PMID: | 29863032 |
Abstract: | 25-Hydroxyvitamin D-3 (25(OH)D-3) as the metabolite of vitamin D, is connected with various of diseases, and important to people with limited sunshine. Thus, the investigation of serum 25-hydroxyvitamin D and its variation in these people is necessary. In this study, a simple, precise, and accurate method for serum 25(OH)D-3 determination by LC/MS/MS was developed. Serum samples were obtained monthly for one year from 11 male and 11 female indoor workers in Sapporo, Japan, and the overall 25(OH)D-3 concentration was 12.9 +/- 4.7 ng/mL. The 25(OH)D-3 in females was significantly lower than that in males (14.0 +/- 5.0 vs. 11.9 +/- 4.3 ng/mL). The serum 25(OH)D-3 concentration in males and females were both strongly correlated to UV-B radiation (r(2) = 0.8477 and 0.7384, respectively), with a two-month's lag. Also the monthly change in 25(OH)D-3 in males was more significant than that in females. |
Type: | article |
URI: | http://hdl.handle.net/2115/71895 |
Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 惠 淑萍
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