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Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers

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Title: Determination of Serum 25-Hydroxyvitamin D-3 by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers
Authors: Okabe, Hiroaki Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Yamamoto, Maiko Browse this author
Kikuchi, Rei Browse this author
Minami, Akiko Browse this author
Chen, Yi-Fan Browse this author
Imai, Hideyuki Browse this author →KAKEN DB
Mizuta, Masahiro Browse this author
Chen, Zhen Browse this author
Chiba, Hitoshi Browse this author →KAKEN DB
Hui, Shu-Ping Browse this author →KAKEN DB
Keywords: 25-Hydroxy vitamin D-3
LC/MS/MS
UV-B
monthly variation
Issue Date: 10-Sep-2018
Publisher: 日本分析化学会
Journal Title: Analytical sciences
Volume: 34
Issue: 9
Start Page: 1043
End Page: 1047
Publisher DOI: 10.2116/analsci.18P193
PMID: 29863032
Abstract: 25-Hydroxyvitamin D-3 (25(OH)D-3) as the metabolite of vitamin D, is connected with various of diseases, and important to people with limited sunshine. Thus, the investigation of serum 25-hydroxyvitamin D and its variation in these people is necessary. In this study, a simple, precise, and accurate method for serum 25(OH)D-3 determination by LC/MS/MS was developed. Serum samples were obtained monthly for one year from 11 male and 11 female indoor workers in Sapporo, Japan, and the overall 25(OH)D-3 concentration was 12.9 +/- 4.7 ng/mL. The 25(OH)D-3 in females was significantly lower than that in males (14.0 +/- 5.0 vs. 11.9 +/- 4.3 ng/mL). The serum 25(OH)D-3 concentration in males and females were both strongly correlated to UV-B radiation (r(2) = 0.8477 and 0.7384, respectively), with a two-month's lag. Also the monthly change in 25(OH)D-3 in males was more significant than that in females.
Type: article
URI: http://hdl.handle.net/2115/71895
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 惠 淑萍

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