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pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives

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Title: pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives
Authors: Nakagawa, Shiori Browse this author
Tachrim, Zetryana Puteri Browse this author
Kurokawa, Natsumi Browse this author
Ohashi, Fumina Browse this author
Sakihama, Yasuko Browse this author →KAKEN DB
Suzuki, Takeyuki Browse this author
Hashidoko, Yasuyuki Browse this author →KAKEN DB
Hashimoto, Makoto Browse this author →KAKEN DB
Keywords: cycloDOPA
pH stability
antioxidant power
Issue Date: 3-Aug-2018
Publisher: MDPI
Journal Title: Molecules
Volume: 23
Issue: 8
Start Page: 1943
Publisher DOI: 10.3390/molecules23081943
Abstract: CycloDOPA (leukodopachrome), a well known metabolite of tyrosine, is a precursor of melanine in mammalian organisms and of the pigment betalain in plants. However, the isolation of cycloDOPA from natural sources has not been widely reported. In the present work, the stabilities of cycloDOPA and cycloDOPA methyl ester at various pH levels were studied. Both compounds were stable under acidic conditions. By contrast, both compounds were unstable when the pH was shifted from neutral to basic to form indole derivatives as major products. Based on the pH stability, cycloDOPA and its derivatives were subjected to the DPPH radical scavenging assay for the first time.
Rights: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 誠

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