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Real-Time Tumor-Tracking Radiotherapy and General Stereotactic Body Radiotherapy for Adrenal Metastasis in Patients With Oligometastasis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/71935

Title: Real-Time Tumor-Tracking Radiotherapy and General Stereotactic Body Radiotherapy for Adrenal Metastasis in Patients With Oligometastasis
Authors: Katoh, Norio Browse this author →KAKEN DB
Onishi, Hiroshi Browse this author →KAKEN DB
Uchinami, Yusuke Browse this author
Inoue, Tetsuya Browse this author →KAKEN DB
Kuriyama, Kengo Browse this author
Nishioka, Kentaro Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Komiyama, Takafumi Browse this author
Miyamoto, Naoki Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: adrenal gland
metastasis
stereotactic body radiotherapy
retrospective
survival rates
Issue Date: 8-Nov-2018
Publisher: SAGE Publications
Journal Title: Technology in Cancer Research & Treatment
Volume: 17
Publisher DOI: 10.1177/1533033818809983
Abstract: Background: Precise local radiotherapy for adrenal metastasis can prolong the useful life of patients with oligometastasis. The aim of this retrospective, 2-center study was to establish the safety and effectiveness of real-time tumor-tracking radiotherapy and general stereotactic body radiotherapy in treating patients with adrenal metastatic tumors. Materials and Methods: Thirteen lesions in 12 patients were treated with real-time tumor-tracking radiotherapy (48 Gy in 8 fractions over 2 weeks) and 8 lesions in 8 patients were treated with general stereotactic body radiotherapy (40-50 Gy in 5-8 fractions over 2 weeks or 60-70 Gy in 10 fractions over 2 weeks). Overall survival rates, local control rates, and adverse effects were analyzed. Results: The actuarial overall survival rates for all patients at 1 and 2 years were 78.5% and 45.8%, respectively, with a median follow-up of 17.5 months, and the actuarial local control rates for all tumors at 1 and 2 years were 91.7% and 53.0%, respectively, with a median follow-up of 9 months. A complete local tumor response was obtained in 3 tumors treated by real-time tumor-tracking radiotherapy (lung adenocarcinomas with diameters of 35, 40, and 60 mm). There was a statistically significant difference in the local control between the groups treated by real-time tumor-tracking radiotherapy (100% at 1 year) and general stereotactic body radiotherapy (50% at 1 year; P < .001). No late adverse reactions at Grade 2 or higher were reported for either treatment group. Conclusions: This study showed that although both treatments are safe and effective, the real-time tumor-tracking radiotherapy is more effective than general stereotactic body radiotherapy in local control for adrenal metastasis.
Rights: https://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/71935
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 徳雄

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