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Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates : The Hokkaido Study on Environment and Children's Health

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Title: Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates : The Hokkaido Study on Environment and Children's Health
Other Titles: Cord blood BPA and reproductive and thyroid hormone levels of neonates
Authors: Minatoya, Machiko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Yamamoto, Jun Browse this author
Matsumura, Toru Browse this author
Mitsui, Takahiko Browse this author
Moriya, Kimihiko Browse this author →KAKEN DB
Cho, Kazutoshi Browse this author →KAKEN DB
Morioka, Keita Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Shinohara, Nobuo Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Issue Date: Oct-2017
Publisher: Wolters Kluwer
Journal Title: Epidemiology
Volume: 28
Start Page: S3
End Page: S9
Publisher DOI: 10.1097/EDE.0000000000000716
PMID: 29028670
Abstract: Background: Bisphenol A (BPA) is widely used and BPA exposure is nearly ubiquitous in developed countries. While animal studies have indicated adverse health effects of prenatal BPA exposure including reproductive dysfunction and thyroid function disruption possibly in sex-specific manner, findings from epidemiological studies have not been enough to proof these adverse effects. Given very limited research on human, the aim of this study was to investigate associations between cord blood BPA levels and reproductive and thyroid hormone levels of neonates and whether associations differed by neonate sex. Methods: Among 514 participants of the Hokkaido study who were recruited from 2002 to 2005 at one hospital in Sapporo, Japan. BPA level in cord blood was determined by ID-LC/MS/MS and the limit of quantification was 0.040 ng/ml. 9 types of reproductive hormone levels in cord blood were measured and thyroid hormone levels were obtained from neonate mass screening test data. 283 subjects those who had both BPA and hormone levels measurements were included for the final analyses. Results: Geometric mean of cord blood BPA was 0.051 ng/ml. After adjustment, BPA level was negatively associated with prolactin (PRL) (β=-0.38). There was an interaction between infant sex and BPA levels on PRL, weak negative association was found in boys (β=-0.12) whereas weak positive association was found in girls (β=0.14). BPA level showed weak positive association with testosterone, estradiol and progesterone levels in boys. No association was found between BPA and thyroid hormone levels. Conclusions: Our findings suggested that fetal BPA levels might be associated with certain reproductive hormone levels of neonate with sex-specific manner, though further investigations are necessary.
Rights: This is a non-final version of an article published in final form in Epidemiology: October 2017, Vol. 28, pp.S3–S9.
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 湊屋 街子

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