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Effect of a 5-HT2c receptor agonist on urethral closure mechanisms in female rats
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| Title: | Effect of a 5-HT2c receptor agonist on urethral closure mechanisms in female rats |
| Authors: | Ouchi, Mifuka Browse this author | | Kitta, Takeya Browse this author →KAKEN DB | | Kanno, Yukiko Browse this author | | Higuchi, Madoka Browse this author | | Togo, Mio Browse this author | | Moriya, Kimihiko Browse this author →KAKEN DB | | Shinohara, Nobuo Browse this author →KAKEN DB |
| Keywords: | 5-HT2c receptor agonist | | active urethral closure mechanism | | lorcaserin | | stress urinary incontinence |
| Issue Date: | Nov-2018 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Neurourology and urodynamics |
| Volume: | 37 |
| Issue: | 8 |
| Start Page: | 2382 |
| End Page: | 2388 |
| Publisher DOI: | 10.1002/nau.23586 |
| PMID: | 29624732 |
| Abstract: | Aims: The serotonin (5-HT2c) receptor is known to be involved in the mechanism of urethral closure in a model of stress incontinence. Lorcaserin (Belviq®) has received Food and Drug Administration approval for the treatment of obesity. However, it is unclear whether this selective 5-HT2c receptor agonist enhances urethral closure in stress urinary incontinence (SUI) models. Therefore, we investigated whether lorcaserin could enhance urethral closure in female rats with vaginal distention (VD). Methods: Normal female rats and rats with stress incontinence induced by VD were tested. We evaluated the effect of a single dose of lorcaserin (0.03, 0.3, or 0.9 mg/kg with cumulative administration) on the urethral pressure amplitude during electrical stimulation (A-URE) and on the urethral baseline pressure (UBP). The manual compression-induced leak point pressure (LPP) was also measured. Results: In VD rats, a single intravenous injection of lorcaserin (0.3 and 0.9 mg/kg) significantly increased both A-URE and LPP compared to saline (P < 0.05). In normal rats, intravenous lorcaserin (0.3 and 0.9 mg/kg) also significantly increased A-URE and LPP compared to saline (P < 0.05). The changes of A-URE and LPP, which are parameters of active urethral closure, were significantly larger in normal rats than in VD rats. Conclusions: We showed that lorcaserin can activate the external urethral sphincter and pelvic floor muscles, suggesting an influence on active closure mechanisms. 5-HT2c receptors agonists may have dual effects in patients with SUI, not only by reducing obesity but also by enhancing active urethral closure. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/72122 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橘田 岳也
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