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Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK

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Title: Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK
Authors: Oyane, Ayako Browse this author
Nakamura, Maki Browse this author
Sakamaki, Ikuko Browse this author
Shimizu, Yoshiki Browse this author
Miyata, Saori Browse this author
Miyaji, Hirofumi Browse this author →KAKEN DB
Issue Date: 31-Oct-2018
Publisher: PLOS
Journal Title: PLoS ONE
Volume: 13
Issue: 10
Start Page: e0206524
Publisher DOI: 10.1371/journal.pone.0206524
Abstract: Calcium phosphate (CaP) coating is an effective method for surface-functionalization of bioinert materials and for production of osteoconductive implants. Recently, we developed a laser-assisted biomimetic process (LAB process) for facile and area-specific CaP coating. In this study, the LAB process was applied to chemically stable and mechanically durable poly(etheretherketone) (PEEK), which has become widely used as an orthopedic and dental implant material. The LAB process was carried out by irradiating pulsed Nd:YAG laser light (355 nm) onto a PEEK substrate that was immersed in supersaturated CaP solution. The CaP coating applicability depended on laser fluence, i.e., CaP successfully formed on PEEK surface after the LAB process at 2 W/cm(2). Further increase in laser fluence did not result in the successful formation. At the optimal fluence of 2 W/cm(2), the laser-irradiated PEEK surface was modified and heated to induce heterogeneous CaP precipitation within 10 min in CaP solution, followed by further CaP growth over the irradiation time (tested up to 30 min). The LAB process improved the cytocompatibility of PEEK surface with osteoblastic MC3T3-E1 cells. Furthermore, the LAB-processed CaP-coated PEEK substrate formed a dense hydroxyapatite layer on its surface in the simulated body fluid, suggesting the osteoconductivity of this material. The present LAB process can be a useful new tool to produce osteoconductive PEEK-based implants.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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