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Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

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Title: Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents
Authors: Hikata, T. Browse this author
Hasegawa, T. Browse this author →KAKEN DB
Horiuchi, K. Browse this author
Fujita, N. Browse this author
Iwanami, A. Browse this author
Watanabe, K. Browse this author
Ishii, K. Browse this author
Nakamura, M. Browse this author
Amizuka, N. Browse this author →KAKEN DB
Matsumoto, M. Browse this author
Keywords: Minimodeling
Issue Date: Dec-2016
Publisher: Elsevier
Journal Title: Bone reports
Volume: 5
Start Page: 286
End Page: 291
Publisher DOI: 10.1016/j.bonr.2016.10.002
Abstract: Minimodeling is a type of focal bone formation that is characterized by the lack of precedent bone erosion by osteoclasts. Although this form of bone formation has been described for more than a decade, how anti-osteoporotic agents that are currently used in clinical practice affect the kinetics of minimodeling is not fully understood. We performed a bone morphometric analysis using human vertebral specimens collected from postmenopausal patients who underwent spinal surgery. Patients were divided into three groups according to osteoporosis medication; non-treated, Eldecalcitol (ELD, a vitamin D derivative that has recently been approved to treat patients with osteoporosis in Japan)-treated, and bisphosphonate-treated groups. Five to six patients were enrolled in each group. There was a trend toward enhanced minimodeling in ELD-treated patients and suppressed of it in bisphosphonate-treated patients compared with untreated patients. The differences of minimodeling activity between ELD-treated and bisphosphonate-treated patients were statistically significant. The present study suggests that ELD and bisphosphonates have opposite effects on minimodeling from one another, and show that minimodeling also takes place in vertebrae as has been described for the ilium and femoral head in humans.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷川 智香

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