| Title: | Ultrastructural and biochemical aspects of matrix vesicle-mediated mineralization |
| Authors: | Hasegawa, T. Browse this author →KAKEN DB |
| Yamamoto, T. Browse this author |
| Tsuchiya, E. Browse this author |
| Hongo, H. Browse this author |
| Tsuboi, K. Browse this author |
| Kudo, A. Browse this author |
| Abe, M. Browse this author |
| Yoshida, T. Browse this author |
| Nagai, T. Browse this author |
| Khadiza, N. Browse this author |
| Yokoyama, A. Browse this author |
| Oda, K. Browse this author →KAKEN DB |
| Ozawa, H. Browse this author |
| Freitas, de PHL. Browse this author |
| Li, Minqi Browse this author →KAKEN DB |
| Amizuka, N. Browse this author →KAKEN DB |
| Keywords: | Matrix vesicle |
| Mineralization |
| TNAP |
| ENPP1 |
| Mineralized nodule |
| Issue Date: | May-2017 |
| Publisher: | Elsevier |
| Journal Title: | Japanese Dental Science Review |
| Volume: | 53 |
| Issue: | 2 |
| Start Page: | 34 |
| End Page: | 45 |
| Publisher DOI: | 10.1016/j.jdsr.2016.09.002 |
| Abstract: | Matrix vesicle-mediated mineralization is an orchestrated sequence of ultrastructural and biochemical events that lead to crystal nucleation and growth. The influx of phosphate ions into the matrix vesicle is mediated by several proteins such as TNAP, ENPP1, Pit1, annexin and so forth. The catalytic activity of ENPP1 generates pyrophosphate (PPi) using extracellular ATPs as a substrate, and the resultant PPi prevents crystal overgrowth. However, TNAP hydrolyzes PPi into phosphate ion monomers, which are then transported into the matrix vesicle through Pit1. Accumulation of Ca2+ and PO43- inside matrix vesicles then induces crystalline nucleation, with calcium phosphate crystals budding off radially, puncturing the matrix vesicle’s membrane and finally growing out of it to form mineralized nodules. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/72299 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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