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Ultrastructural and biochemical aspects of matrix vesicle-mediated mineralization

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Title: Ultrastructural and biochemical aspects of matrix vesicle-mediated mineralization
Authors: Hasegawa, T. Browse this author →KAKEN DB
Yamamoto, T. Browse this author
Tsuchiya, E. Browse this author
Hongo, H. Browse this author
Tsuboi, K. Browse this author
Kudo, A. Browse this author
Abe, M. Browse this author
Yoshida, T. Browse this author
Nagai, T. Browse this author
Khadiza, N. Browse this author
Yokoyama, A. Browse this author
Oda, K. Browse this author →KAKEN DB
Ozawa, H. Browse this author
Freitas, de PHL. Browse this author
Li, Minqi Browse this author →KAKEN DB
Amizuka, N. Browse this author →KAKEN DB
Keywords: Matrix vesicle
Mineralized nodule
Issue Date: May-2017
Publisher: Elsevier
Journal Title: Japanese Dental Science Review
Volume: 53
Issue: 2
Start Page: 34
End Page: 45
Publisher DOI: 10.1016/j.jdsr.2016.09.002
Abstract: Matrix vesicle-mediated mineralization is an orchestrated sequence of ultrastructural and biochemical events that lead to crystal nucleation and growth. The influx of phosphate ions into the matrix vesicle is mediated by several proteins such as TNAP, ENPP1, Pit1, annexin and so forth. The catalytic activity of ENPP1 generates pyrophosphate (PPi) using extracellular ATPs as a substrate, and the resultant PPi prevents crystal overgrowth. However, TNAP hydrolyzes PPi into phosphate ion monomers, which are then transported into the matrix vesicle through Pit1. Accumulation of Ca2+ and PO43- inside matrix vesicles then induces crystalline nucleation, with calcium phosphate crystals budding off radially, puncturing the matrix vesicle’s membrane and finally growing out of it to form mineralized nodules.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷川 智香

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