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Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study : a prospective birth cohort

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Title: Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study : a prospective birth cohort
Authors: Kobayashi, Sumitaka Browse this author →KAKEN DB
Sata, Fumihiro Browse this author
Hanaoka, Tomoyuki Browse this author
Braimoh, Titilola Serifat Browse this author
Ito, Kumiko Browse this author
Tamura, Naomi Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Issue Date: Feb-2019
Publisher: BMJ Publishing Group
Journal Title: BMJ Open
Volume: 9
Issue: 2
Start Page: e023200
Publisher DOI: 10.1136/bmjopen-2018-023200
PMID: 30782875
Abstract: Objectives: To investigate the association between plasma cotinine level measured at the 8th gestational month and the delivery of small-for-gestational-age (SGA) infants, using a highly sensitive ELISA method. Design: Prospective birth cohort study from The Hokkaido Study on Environment and Children's Health. Setting: Hokkaido, Japan. Participants: Our sample included 15 198 mother-infant pairs enrolled in 2003-2012. Main outcome measures: SGA, defined as a gestational age-specific weight Z-score below -2. Results: The number of SGA infants was 192 (1.3%). The cotinine cut-off level that differentiated SGA infants from other infants was 3.03 ng/mL for both the total population and the full-term births subgroup (sensitivity 0.307; positive predictive value 2.3%). Compared with infants of mothers with a plasma cotinine level of <3.03 ng/mL, infants of mothers with a plasma cotinine level of ≥3.03 ng/mL showed an increased OR for SGA in the total population and the full-term infant group (2.02(95% CI 1.45 to 2.83) and 2.44(95% CI 1.73 to 3.44), respectively). Conclusion: A plasma cotinine level of ≥3.03 ng/mL, which included both passive and active smokers, was associated with an increased risk of SGA. This finding is of important relevance when educating pregnant women about avoiding prenatal passive and active smoking due to the adverse effects on their infants, even those born at full-term.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/72499
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 澄貴

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