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Hokkaido University Collection of Scholarly and Academic Papers >
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Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment : Advances and Challenges
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| Title: | Exploring lncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment : Advances and Challenges |
| Authors: | Dong, Peixin Browse this author →KAKEN DB | | Xiong, Ying Browse this author | | Yue, Junming Browse this author | | Hanley, Sharon J. B. Browse this author →KAKEN DB | | Kobayashi, Noriko Browse this author | | Todo, Yukiharu Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | long non-coding RNA | | microRNA | | endometrial cancer | | prognostic biomarker | | therapeutic target | | epigenetics | | regulatory mechanism | | tumor microenvironment |
| Issue Date: | Feb-2019 |
| Publisher: | MDPI |
| Journal Title: | Cancers |
| Volume: | 11 |
| Issue: | 2 |
| Start Page: | 234 |
| Publisher DOI: | 10.3390/cancers11020234 |
| PMID: | 30781521 |
| Abstract: | Recent studies have revealed both the promise and challenges of targeting long non-coding RNAs (lncRNAs) to diagnose and treat endometrial cancer (EC). LncRNAs are upregulated or downregulated in ECs compared to normal tissues and their dysregulation has been linked to tumor grade, FIGO stage, the depth of myometrial invasion, lymph node metastasis and patient survival. Tumor suppressive lncRNAs (GAS5, MEG3, FER1L4 and LINC00672) and oncogenic lncRNAs (CCAT2, BANCR, NEAT1, MALAT1, H19 and Linc-RoR) have been identified as upstream modulators or downstream effectors of major signaling pathways influencing EC metastasis, including the PTEN/PI3K/AKT/mTOR, RAS/RAF/MEK/ERK, WNT/β-catenin and p53 signaling pathways. TUG1 and TDRG1 stimulate the VEGF-A pathway. PCGEM1 is implicated in activating the JAK/STAT3 pathway. Here, we present an overview of the expression pattern, prognostic value, biological function of lncRNAs in EC cells and their roles within the tumor microenvironment, focusing on the influence of lncRNAs on established EC-relevant pathways. We also describe the emerging classification of EC subtypes based on their lncRNA signature and discuss the clinical implications of lncRNAs as valuable biomarkers for EC diagnosis and potential targets for EC treatment. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/72604 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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