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Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212) : Dose-finding phase

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Title: Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212) : Dose-finding phase
Other Titles: A dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (JCOG1212) : dose-finding phase
Intra-arterial CRT for maxillary sinus cancer
Authors: Homma, Akihiro Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Matsuura, Kazuto Browse this author →KAKEN DB
Shinomiya, Hirotaka Browse this author
Sakashita, Tomohiro Browse this author →KAKEN DB
Shiga, Kiyoto Browse this author →KAKEN DB
Tachibana, Hiroyuki Browse this author
Nakamura, Kenichi Browse this author
Mizusawa, Junki Browse this author
Kitahara, Hideaki Browse this author
Eba, Junko Browse this author
Fukuda, Haruhiko Browse this author
Fujii, Masato Browse this author →KAKEN DB
Hayashi, Ryuichi Browse this author
Keywords: chemoradiotherapy
cisplatin
intra-arterial
maxillary sinus cancer
squamous cell carcinoma
Issue Date: Mar-2018
Publisher: John Wiley & Sons
Journal Title: Head & neck
Volume: 40
Issue: 3
Start Page: 475
End Page: 484
Publisher DOI: 10.1002/hed.25001
PMID: 29130565
Abstract: BACKGROUND: We are currently undertaking a multi-institutional prospective trial of the superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy for patients with T4aN0M0 or T4bN0M0 locally advanced maxillary sinus squamous cell carcinomas (MS-SCC). We herein report the results of the dose-finding phase. METHODS: The dose-finding phase sought to evaluate the incidence of dose-limiting toxicities (DLTs) and determine the recommended number of cycles (RC) of the intra-arterial infusion of cisplatin. In this phase, 100 mg/m2 of cisplatin was administered intra-arterially weekly for 7 weeks with concomitant radiotherapy (70 Gy). RESULTS: All 18 patients received a full dose of radiotherapy. The number of cycles of cisplatin was 7 in 13 patients and 6 in 5 patients. DLT was observed in 5 patients. CONCLUSIONS: These results indicated that this therapy is safe and well-tolerated at 7 cycles of cisplatin, which was determined to be the RC for locally advanced MS-SCC.
Rights: This is the peer reviewed version of the following article: Homma A, Onimaru R, Matsuura K, et al. Dose-finding and efficacy confirmation trial of the superselective intra‐arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (Japan Clinical Oncology Group 1212): Dose-finding phase. Head & Neck. 2018;40:475–484, which has been published in final form at https://doi.org/10.1002/hed.25001. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/72733
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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