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The logic of biologically active small molecules : amazing ability of microorganisms

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/73224

Title: The logic of biologically active small molecules : amazing ability of microorganisms
Authors: Ubukata, Makoto Browse this author →KAKEN DB
Keywords: Liposidomycin
tautomycin
tautomycetin
zincmethylphyrin
uncultured Actinobacteria
Issue Date: 21-Mar-2018
Publisher: Taylor & Francis
Journal Title: Bioscience, biotechnology, and biochemistry
Volume: 82
Issue: 7
Start Page: 1063
End Page: 1072
Publisher DOI: 10.1080/09168451.2018.1451740
Abstract: In this review article, I will outline my way of thinking about biologically active small molecules. The structure of liposidomycin B from Streptomyces species resulted in my initial sense that a structure tells its function. A biologically active small molecule may save directly or indirectly a number of people. Even if the molecule has not been used as a therapeutic agent, it can be used as a useful chemical probe for dissecting a living cell into different biochemical pieces. Such biologically active small molecules derived from microorganisms have been primarily found in cultivable microorganisms that make up only 1% of total microbes in nature. Discovery of novel growth factors, zincmethylphyrin, zinc coproporphyrin, and coproporphyrin enabled laboratory cultivation of previously uncultured Leucobacter sp. These findings might expand the possibility for further discovery of novel therapeutic agents or chemical probes.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry on 21 Mar 2018, available online: https://doi.org/10.1080/09168451.2018.1451740
Type: article (author version)
URI: http://hdl.handle.net/2115/73224
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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