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Modifying oligoalanine conformation by replacement of amide to ester linkage

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Title: Modifying oligoalanine conformation by replacement of amide to ester linkage
Authors: Hongen, Takahiro Browse this author
Taniguchi, Tohru Browse this author →KAKEN DB
Monde, Kenji Browse this author →KAKEN DB
Keywords: electronic circular dichroism
lactic acid
polyproline type II helix
vibrational circular dichroism
Issue Date: Apr-2018
Publisher: John Wiley & Sons
Journal Title: Chirality
Volume: 30
Issue: 4
Start Page: 396
End Page: 401
Publisher DOI: 10.1002/chir.22823
PMID: 29417636
Abstract: Oligo(lactic acid) is an ester-analogue of short oligoalanine sequence and adopts a rigid left-handed helical structure. In this study, oligo(lactic acid) was incorporated into oligoalanine sequences and their conformations were studied by vibrational circular dichroism and electronic circular dichroism spectroscopy. The results suggested that oligo(lactic acid) moiety in these sequences maintains a left-handed helix and increases the conformational propensity of the oligoalanine moiety to form a left-handed polyproline type II-like helix. The importance of the chirality of oligo(lactic acid) moiety for the oligoalanine conformation was also studied. The results obtained in this study should be useful in developing ester-containing oligopeptides that function better than normal peptides.
Rights: This is the peer reviewed version of the following article: Chirality. Volume30, Issue4 April 2018 Pages 396-401 This article also appears in: Special Issue: Proceedings 16th International Conference on Chiroptical Spectroscopy, Rennes France 2017 (Volume 30, 2018) which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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