| Title: | Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis |
| Authors: | Nakajima, Takayuki Browse this author |
| Yokota, Takashi Browse this author →KAKEN DB |
| Shingu, Yasushige Browse this author →KAKEN DB |
| Yamada, Akira Browse this author |
| Iba, Yutaka Browse this author |
| Ujihira, Kosuke Browse this author |
| Wakasa, Satoru Browse this author →KAKEN DB |
| Ooka, Tomonori Browse this author |
| Takada, Shingo Browse this author →KAKEN DB |
| Shirakawa, Ryosuke Browse this author |
| Katayama, Takashi Browse this author |
| Furihata, Takaaki Browse this author →KAKEN DB |
| Fukushima, Arata Browse this author →KAKEN DB |
| Matsuoka, Ryosuke Browse this author |
| Nishihara, Hiroshi Browse this author →KAKEN DB |
| Dela, Flemming Browse this author |
| Nakanishi, Katsuhiko Browse this author |
| Matsui, Yoshiro Browse this author →KAKEN DB |
| Kinugawa, Shintaro Browse this author →KAKEN DB |
| Issue Date: | 5-Mar-2019 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 9 |
| Start Page: | 3535 |
| Publisher DOI: | 10.1038/s41598-019-40419-7 |
| PMID: | 30837669 |
| Abstract: | Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n= 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/73565 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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