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Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis

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Title: Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis
Authors: Nakajima, Takayuki Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Shingu, Yasushige Browse this author →KAKEN DB
Yamada, Akira Browse this author
Iba, Yutaka Browse this author
Ujihira, Kosuke Browse this author
Wakasa, Satoru Browse this author →KAKEN DB
Ooka, Tomonori Browse this author
Takada, Shingo Browse this author →KAKEN DB
Shirakawa, Ryosuke Browse this author
Katayama, Takashi Browse this author
Furihata, Takaaki Browse this author →KAKEN DB
Fukushima, Arata Browse this author →KAKEN DB
Matsuoka, Ryosuke Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Dela, Flemming Browse this author
Nakanishi, Katsuhiko Browse this author
Matsui, Yoshiro Browse this author →KAKEN DB
Kinugawa, Shintaro Browse this author →KAKEN DB
Issue Date: 5-Mar-2019
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 9
Start Page: 3535
Publisher DOI: 10.1038/s41598-019-40419-7
PMID: 30837669
Abstract: Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n= 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/73565
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 横田 卓

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