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Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment
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| Title: | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
| Authors: | Nomoto, Hiroshi Browse this author | | Kameda, Hiraku Browse this author | | Nakamura, Akinobu Browse this author →KAKEN DB | | Tsuchida, Kazuhisa Browse this author | | Nagai, So Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB | | Miyoshi, Hideaki Browse this author →KAKEN DB |
| Keywords: | autonomously functioning thyroid nodule | | acromegaly | | somatostatin analog | | pituitary adenoma | | thyrotoxicosis |
| Issue Date: | 1-Mar-2019 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in Endocrinology |
| Volume: | 10 |
| Start Page: | 131 |
| Publisher DOI: | 10.3389/fendo.2019.00131 |
| PMID: | 30881346 |
| Abstract: | Patients with acromegaly are at increased risk of developing certain tumors, including goiter and thyroid nodules, and occasionally autonomous thyroid nodules. A 53-year-old woman presented at our hospital with untreated acromegaly. She had typical physical features of acromegaly with pituitary adenoma, and thyrotoxicosis with thyroid-stimulating hormone suppression was also confirmed. Thyroid ultrasonography and scintigraphy showed an autonomously functioning thyroid nodule on her right lobe. Because her thyrotoxicosis was mild, she was initially treated with octreotide for acromegaly. However, 1 month after octreotide administration, she developed neck pain and fever with transient thyrotoxicosis. The blood flow around the nodule then decreased and the excess trapping of isotope detected by scintigraphy was reduced, followed by normalization of insulin-like growth factor-1 levels and thyroid function. This case suggests that octreotide may have unexpected effects on autonomous thyroid nodules. However, further studies are needed to determine the clinical course of autonomously functioning thyroid nodules, including thyroid function and tumor manifestations, during octreotide therapy. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/73566 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 三好 秀明
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