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Smooth muscle-like Ca(2+)-regulation of actin-myosin interaction in adult jellyfish striated muscle

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Title: Smooth muscle-like Ca(2+)-regulation of actin-myosin interaction in adult jellyfish striated muscle
Authors: Tanaka, Hiroyuki Browse this author →KAKEN DB
Ishimaru, Shiori Browse this author
Nagatsuka, Yasuhiro Browse this author
Ohashi, Keisuke Browse this author
Issue Date: 17-May-2018
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 8
Start Page: 7776
Publisher DOI: 10.1038/s41598-018-24817-x
Abstract: Cnidaria is an animal phylum, whose members probably have the most ancestral musculature. We prepared and characterized, for the first time to our knowledge, native actomyosin from the striated myoepithelium of the adult moon jelly Aurelia sp. The actomyosin contained myosin, paramyosin-like protein, Ser/Thr-kinase, actin, and two isoforms of tropomyosin, but not troponin, which is known to activate contraction dependent on intracellularCa(2+) signaling in almost all striated muscles of bilaterians. Notably, the myosin comprised striated muscle-type heavy chain and smooth muscle-type regulatory light chains. In the presence of Ca2+, the Mg-ATPase activity of actomyosin was stimulated and Ser21 of the regulatory light chain was concomitantly phosphorylated by the addition of calmodulin and myosin light chain kinase prepared from chicken smooth muscle. Collectively, these results suggest that, similar to smooth muscle, the contraction of jellyfish striated muscle is regulated by Ca2+-dependent phosphorylation of the myosin light chain.
Type: article
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 啓之

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