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Involvement of 11-ketotestosterone in hooknose formation in male pink salmon (Oncorhynchus gorbuscha) jaws
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| Title: | Involvement of 11-ketotestosterone in hooknose formation in male pink salmon (Oncorhynchus gorbuscha) jaws |
| Authors: | Kudo, Hideaki Browse this author →KAKEN DB | | Kimura, Tomoaki Browse this author | | Hasegawa, Yuya Browse this author | | Abe, Takashi Browse this author | | Ichimura, Masaki Browse this author | | Ijiri, Shigeho Browse this author →KAKEN DB |
| Keywords: | 11-ketotestosterone | | Androgen receptor | | Hooknose | | Secondary sexual characteristic | | Pink salmon | | Cartilage | | Bone |
| Issue Date: | 1-May-2018 |
| Publisher: | Elsevier |
| Journal Title: | General and Comparative Endocrinology |
| Volume: | 260 |
| Start Page: | 41 |
| End Page: | 50 |
| Publisher DOI: | 10.1016/j.ygcen.2018.02.009 |
| Abstract: | Mature male Pacific salmon (Oncorhynchus spp.) develop a hooknose, as a secondary male sexual characteristic, during the spawning period. It is likely that androgens regulate hooknose formation. However, endocrinological and histochemical details about the relationship between androgens and hooknose formation are poorly understood. In this study, we performed assays of serum androgens, detection of androgen receptor (AR) in hooknose tissues, external morphological measurement of hooknose-related lengths, and microscopic observation of hooknose tissues of pink salmon (O. gorbuscha) at different stages of sexual maturation. Expression of the ar beta gene was detected in hooknose tissues of males but not females. The elongation of these tissues was mediated directly via androgens. Serum 11-ketotestosterone (11-KT) concentrations indicated a significant positive correlation with both jaw lengths during sexual maturation of males. In the upper jaw, cartilage tissue developed during hooknose formation, and AR-immunoreactive chondrocytes were located in the rostal-vetral regions of hooknose cartilage in maturing male. The chondrocytes in maturing males before entering into rivers exhibited rich cytoplasm with high cell activity than at other sexual development stages. On the other hand, in the lower jaw, the development of the spongiosa-like bone meshworks. AR-immunoreactivity was detected in a proportion of the osteocytes and osteoblast-like cells in the spongiosa-like bone meshworks. These results indicate that hooknose formation in pink salmon, which is associated with the buildup of a structure with sufficient strength that it can be used to attack other males on the spawning ground, is regulated by 11-KT. (C) 2018 Elsevier Inc. All rights reserved. |
| Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/73801 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 工藤 秀明
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