| Title: | Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on F-18-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma |
| Authors: | Senjo, Hajime Browse this author |
| Kanaya, Minoru Browse this author |
| Izumiyama, Koh Browse this author |
| Minauch, Koichiro Browse this author |
| Hirata, Kenji Browse this author →KAKEN DB |
| Mori, Akio Browse this author |
| Saito, Makoto Browse this author |
| Tanaka, Masanori Browse this author |
| Iijima, Hiroaki Browse this author |
| Tsukamoto, Eriko Browse this author |
| Itoh, Kazuo Browse this author →KAKEN DB |
| Ota, Shuichi Browse this author |
| Morioka, Masanobu Browse this author |
| Hashimoto, Daigo Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | diffuse large B-cell lymphoma |
| soluble interleukin-2 receptor |
| total metabolic tumor volume |
| Issue Date: | Mar-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Cancer medicine |
| Volume: | 8 |
| Issue: | 3 |
| Start Page: | 953 |
| End Page: | 962 |
| Publisher DOI: | 10.1002/cam4.1973 |
| PMID: | 30790452 |
| Abstract: | Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using F-18-FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of F-18-FDG PET/CT. In order to explore a surrogate marker for TMTV, we evaluated the correlation between the serum levels of soluble interleukin-2 receptor (sIL-2R) and TMTV in 64 patients with DLBCL, and the results were verified in an independent validation cohort of 86 patients. Serum levels of sIL-2R were significantly correlated with TMTV. ROC analysis revealed that the cutoff value of TMTV >= 150 cm(3) or sIL-2R >= 1300 U/mL could predict failure to achieve EFS24 with areas under the curve (AUC) 0.706 and 0.758, respectively. Each of TMTV >= 150 cm(3) and sIL-2R >= 1300 U/mL was significantly associated with worse 5-year overall survival and event-free survival. Importantly, each of sIL-2R <1300 U/mL or TMTV <150 cm(3) identified patients with favorable prognosis among NCCN-IPI high-intermediate and high-risk group. Serum level of sIL-2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by F-18-FDG PET/CT that can predict treatment outcomes of patients with DLBCL. |
| Rights: | Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma / Senjo H, Kanaya M, Izumiyama K, et al. / Cancer Medicine 8(3).(c) 2019 The Authors. |
| https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/73845 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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