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Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on F-18-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/73845

Title: Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on F-18-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma
Authors: Senjo, Hajime Browse this author
Kanaya, Minoru Browse this author
Izumiyama, Koh Browse this author
Minauch, Koichiro Browse this author
Hirata, Kenji Browse this author →KAKEN DB
Mori, Akio Browse this author
Saito, Makoto Browse this author
Tanaka, Masanori Browse this author
Iijima, Hiroaki Browse this author
Tsukamoto, Eriko Browse this author
Itoh, Kazuo Browse this author →KAKEN DB
Ota, Shuichi Browse this author
Morioka, Masanobu Browse this author
Hashimoto, Daigo Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Keywords: diffuse large B-cell lymphoma
soluble interleukin-2 receptor
total metabolic tumor volume
Issue Date: Mar-2019
Publisher: John Wiley & Sons
Journal Title: Cancer medicine
Volume: 8
Issue: 3
Start Page: 953
End Page: 962
Publisher DOI: 10.1002/cam4.1973
PMID: 30790452
Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using F-18-FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of F-18-FDG PET/CT. In order to explore a surrogate marker for TMTV, we evaluated the correlation between the serum levels of soluble interleukin-2 receptor (sIL-2R) and TMTV in 64 patients with DLBCL, and the results were verified in an independent validation cohort of 86 patients. Serum levels of sIL-2R were significantly correlated with TMTV. ROC analysis revealed that the cutoff value of TMTV >= 150 cm(3) or sIL-2R >= 1300 U/mL could predict failure to achieve EFS24 with areas under the curve (AUC) 0.706 and 0.758, respectively. Each of TMTV >= 150 cm(3) and sIL-2R >= 1300 U/mL was significantly associated with worse 5-year overall survival and event-free survival. Importantly, each of sIL-2R <1300 U/mL or TMTV <150 cm(3) identified patients with favorable prognosis among NCCN-IPI high-intermediate and high-risk group. Serum level of sIL-2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by F-18-FDG PET/CT that can predict treatment outcomes of patients with DLBCL.
Rights: Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma / Senjo H, Kanaya M, Izumiyama K, et al. / Cancer Medicine 8(3).(c) 2019 The Authors.
https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/73845
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 千丈 創

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