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Discovery of Mwinilunga alphavirus : A novel alphavirus in Culex mosquitoes in Zambia

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Title: Discovery of Mwinilunga alphavirus : A novel alphavirus in Culex mosquitoes in Zambia
Authors: Torii, Shiho Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Wada, Yuji Browse this author
Anindita, Paulina D. Browse this author
Phongphaew, Wallaya Browse this author
Qiu, Yongjin Browse this author
Kajihara, Masahiro Browse this author
Mori-Kajihara, Akina Browse this author
Eto, Yoshiki Browse this author
Harima, Hayato Browse this author
Sasaki, Michihito Browse this author
Carr, Michael Browse this author
Hall, William W. Browse this author
Eshita, Yuki Browse this author
Abe, Takashi Browse this author
Sawa, Hirofumi Browse this author
Keywords: Alphavirus
Issue Date: 2-May-2018
Publisher: Elsevier
Journal Title: Virus Research
Volume: 250
Start Page: 31
End Page: 36
Publisher DOI: 10.1016/j.virusres.2018.04.005
Abstract: Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes. From 552 mosquito pools, a novel alphavirus, tentatively named Mwinilunga alphavirus (MWAV), was discovered from a single Culex quinquefasciatus mosquito pool. The full genome of MWAV was subsequently determined, and pairwise comparisons demonstrated that MWAV represented a new alphavirus species. Phylogenetic analyses and a linear discriminant analysis based on the dinucleotide ratios in various virus sequences indicated that MWAV is related to a mosquito-specific alphavirus distinct from other known mosquito-borne alphaviruses due to its inability to replicate in vertebrate cell lines. Further analyses of these novel alphaviruses will help to facilitate a greater understanding of the molecular determinants of host range restriction and the evolutionary relationships of alphaviruses.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大場 靖子

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