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Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis : A case report and experimental investigation
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| Title: | Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis : A case report and experimental investigation |
| Authors: | Sato, Kazuki Browse this author | | Ohira, Hiroshi Browse this author →KAKEN DB | | Horinouchi, Takahiro Browse this author →KAKEN DB | | Nakaya, Toshitaka Browse this author | | Mazaki, Yuichi Browse this author | | Sugimoto, Ayako Browse this author | | Watanabe, Taku Browse this author →KAKEN DB | | Tsujino, Ichizo Browse this author →KAKEN DB | | Nishimura, Masaharu Browse this author →KAKEN DB |
| Keywords: | Adverse event | | Qing-Dai | | Pulmonary arterial hypertension | | Indigo |
| Issue Date: | 2019 |
| Publisher: | Elsevier |
| Journal Title: | Respiratory medicine case reports |
| Volume: | 26 |
| Start Page: | 265 |
| End Page: | 269 |
| Publisher DOI: | 10.1016/j.rmcr.2019.02.007 |
| PMID: | 30815357 |
| Abstract: | A recent case report described a case of pulmonary arterial hypertension (PAH) associated with use of the Chinese herbal medicine Qing-Dai; however, the clinical course and possible mechanisms have not been characterized. We present the case of a man with ulcerative colitis who was diagnosed with idiopathic PAH. After initiating oral beraprost therapy, the patient showed significant hemodynamic improvements and an unusual course of clinical recovery. In 2016, the Japanese Ministry of Health, Labour, and Welfare issued a warning regarding the possible side effects of Qing-Dai. We learned that our patient had been taking self-purchased Qing-Dai for 2 years. Therefore, we performed an experimental study and determined that Qing-Dai may cause PAH through a mechanism involving nitric oxide synthase inhibition and pulmonary artery endothelial dysfunction. |
| Rights: | © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/73901 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大平 洋
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