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Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis : A case report and experimental investigation

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Title: Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis : A case report and experimental investigation
Authors: Sato, Kazuki Browse this author
Ohira, Hiroshi Browse this author →KAKEN DB
Horinouchi, Takahiro Browse this author →KAKEN DB
Nakaya, Toshitaka Browse this author
Mazaki, Yuichi Browse this author
Sugimoto, Ayako Browse this author
Watanabe, Taku Browse this author →KAKEN DB
Tsujino, Ichizo Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Adverse event
Qing-Dai
Pulmonary arterial hypertension
Indigo
Issue Date: 2019
Publisher: Elsevier
Journal Title: Respiratory medicine case reports
Volume: 26
Start Page: 265
End Page: 269
Publisher DOI: 10.1016/j.rmcr.2019.02.007
PMID: 30815357
Abstract: A recent case report described a case of pulmonary arterial hypertension (PAH) associated with use of the Chinese herbal medicine Qing-Dai; however, the clinical course and possible mechanisms have not been characterized. We present the case of a man with ulcerative colitis who was diagnosed with idiopathic PAH. After initiating oral beraprost therapy, the patient showed significant hemodynamic improvements and an unusual course of clinical recovery. In 2016, the Japanese Ministry of Health, Labour, and Welfare issued a warning regarding the possible side effects of Qing-Dai. We learned that our patient had been taking self-purchased Qing-Dai for 2 years. Therefore, we performed an experimental study and determined that Qing-Dai may cause PAH through a mechanism involving nitric oxide synthase inhibition and pulmonary artery endothelial dysfunction.
Rights: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/73901
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大平 洋

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