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Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients
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| Title: | Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients |
| Authors: | Fujima, Noriyuki Browse this author →KAKEN DB | | Sakashita, Tomohiro Browse this author →KAKEN DB | | Homma, Akihiro Browse this author →KAKEN DB | | Yoshida, Daisuke Browse this author | | Kudo, Kohsuke Browse this author →KAKEN DB | | Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | diffusion-weighted imaging | | intravoxel incoherent motion | | diffusional kurtosis imaging | | head and neck squamous cell carcinoma |
| Issue Date: | 2018 |
| Publisher: | Japan Society of Magnetic Resonance in Medicine |
| Journal Title: | Magnetic Resonance in Medical Sciences |
| Volume: | 17 |
| Issue: | 1 |
| Start Page: | 21 |
| End Page: | 27 |
| Publisher DOI: | 10.2463/mrms.mp.2016-0136 |
| PMID: | 28515412 |
| Abstract: | Purpose: To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients.
Materials and Methods: We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0–2000) was performed in all patients before any treatment. We calculated the IVIM-DKI parameters and the conventional apparent diffusion coefficient (ADC) in the ROI placed on the primary lesion. The presence of future distant metastasis was determined by histological findings or clinical follow-up.
Results: A univariate analysis revealed significant differences between the patients with distant metastasis and those without in slow diffusion coefficient (D) and kurtosis value (K). Highest diagnostic accuracy was obtained by the D value. In addition, a multivariate analysis revealed that the D value was an independent predictor of future distant metastasis.
Conclusion: The D and K values obtained by this hybrid IVIM-DKI model can be one of the diagnostic tools for the prediction of future distant metastasis in HNSCC patients. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/74024 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 藤間 憲幸
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