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Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T : Comparison with O-15-labeled Water Positron Emission Tomography

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Title: Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T : Comparison with O-15-labeled Water Positron Emission Tomography
Authors: Kikuchi, Yasuka Browse this author →KAKEN DB
Naya, Masanao Browse this author →KAKEN DB
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Manabe, Osamu Browse this author →KAKEN DB
Sugimori, Hiroyuki Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Kato, Fumi Browse this author →KAKEN DB
Aikawa, Tadao Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: coronary artery disease
coronary flow velocity reserve
magnetic resonance imaging
phase contrast
3 tesla
Issue Date: 2019
Publisher: Japanese Society for Magnetic Resonance in Medicine
Journal Title: Magnetic resonance in medical sciences
Volume: 18
Issue: 2
Start Page: 134
End Page: 141
Publisher DOI: 10.2463/mrms.mp.2018-0003
PMID: 30047496
Abstract: Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by O-15-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R-2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 +/- 0.61 vs. 2.77 +/- 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 +/- 0.84 vs. 3.96 +/- 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/74040
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 納谷 昌直

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