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Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

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Title: Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing
Authors: Yasukawa, Shinichiro Browse this author
Kano, Satoshi Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Nakamaru, Yuji Browse this author →KAKEN DB
Takagi, Dai Browse this author
Mizumachi, Takatsugu Browse this author →KAKEN DB
Suzuki, Masanobu Browse this author
Suzuki, Takayoshi Browse this author
Nakazono, Akira Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Nishihara, Hiroshi Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Keywords: Inverted papilloma
Malignant transformation
Squamous cell carcinoma
Targeted amplicon sequence
Issue Date: Oct-2018
Publisher: Springer
Journal Title: International journal of clinical oncology
Volume: 23
Issue: 5
Start Page: 835
End Page: 843
Publisher DOI: 10.1007/s10147-018-1296-1
PMID: 29779136
Abstract: Background: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. Methods: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. Results: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Conclusion: Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
Rights: This is a post-peer-review, pre-copyedit version of an article published in International Journal of Clinical Oncology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加納 里志

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