Title: | Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing |
Authors: | Yasukawa, Shinichiro Browse this author |
Kano, Satoshi Browse this author →KAKEN DB |
Hatakeyama, Hiromitsu Browse this author →KAKEN DB |
Nakamaru, Yuji Browse this author →KAKEN DB |
Takagi, Dai Browse this author |
Mizumachi, Takatsugu Browse this author →KAKEN DB |
Suzuki, Masanobu Browse this author |
Suzuki, Takayoshi Browse this author |
Nakazono, Akira Browse this author |
Tanaka, Shinya Browse this author →KAKEN DB |
Nishihara, Hiroshi Browse this author →KAKEN DB |
Homma, Akihiro Browse this author →KAKEN DB |
Keywords: | Inverted papilloma |
Malignant transformation |
Squamous cell carcinoma |
Targeted amplicon sequence |
NGS |
Issue Date: | Oct-2018 |
Publisher: | Springer |
Journal Title: | International journal of clinical oncology |
Volume: | 23 |
Issue: | 5 |
Start Page: | 835 |
End Page: | 843 |
Publisher DOI: | 10.1007/s10147-018-1296-1 |
PMID: | 29779136 |
Abstract: | Background: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. Methods: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. Results: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Conclusion: Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP. |
Rights: | This is a post-peer-review, pre-copyedit version of an article published in International Journal of Clinical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10147-018-1296-1 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/74188 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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