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Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin

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Title: Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin
Authors: Kawabori, Masahito Browse this author →KAKEN DB
Kurisu, Kota Browse this author
Niiya, Yoshimasa Browse this author
Ohta, Yuzuru Browse this author
Mabuchi, Shoji Browse this author
Houkin, Kiyohiro Browse this author →KAKEN DB
Keywords: Mollaret meningitis
recurrent aseptic meningitis
fever
indomethacin
cytokines
Issue Date: 15-Apr-2019
Publisher: 日本内科学会
Journal Title: Internal medicine
Volume: 58
Issue: 8
Start Page: 1163
End Page: 1166
Publisher DOI: 10.2169/internalmedicine.1676-18
PMID: 30568139
Abstract: A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during a three-year period is reported. The patient showed a high fever and severe headache accompanied by a high level of cerebrospinal fluid (CSF) cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). The symptoms and high CSF cytokines were resolved immediately after introducing indomethacin treatment. Reactivation of the latent virus is considered to be the cause of this rare disease, and indomethacin is believed to inhibit the periodic abnormal generation of eicosanoid in the brain, resulting in a reduction in the fever and subsequent inflammation.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/74484
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川堀 真人

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