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Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin
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| Title: | Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin |
| Authors: | Kawabori, Masahito Browse this author →KAKEN DB | | Kurisu, Kota Browse this author | | Niiya, Yoshimasa Browse this author | | Ohta, Yuzuru Browse this author | | Mabuchi, Shoji Browse this author | | Houkin, Kiyohiro Browse this author →KAKEN DB |
| Keywords: | Mollaret meningitis | | recurrent aseptic meningitis | | fever | | indomethacin | | cytokines |
| Issue Date: | 15-Apr-2019 |
| Publisher: | 日本内科学会 |
| Journal Title: | Internal medicine |
| Volume: | 58 |
| Issue: | 8 |
| Start Page: | 1163 |
| End Page: | 1166 |
| Publisher DOI: | 10.2169/internalmedicine.1676-18 |
| PMID: | 30568139 |
| Abstract: | A rare case of Mollaret meningitis characterized by four recurrent episodes of aseptic meningitis during a three-year period is reported. The patient showed a high fever and severe headache accompanied by a high level of cerebrospinal fluid (CSF) cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). The symptoms and high CSF cytokines were resolved immediately after introducing indomethacin treatment. Reactivation of the latent virus is considered to be the cause of this rare disease, and indomethacin is believed to inhibit the periodic abnormal generation of eicosanoid in the brain, resulting in a reduction in the fever and subsequent inflammation. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/74484 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 川堀 真人
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