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Congenital nevi with hypomelanosis and fine scales

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/74488

Title: Congenital nevi with hypomelanosis and fine scales
Authors: Natsuga, Ken Browse this author →KAKEN DB
Oiso, Naoki Browse this author →KAKEN DB
Kurokawa, Ichiro Browse this author
Tsubura, Airo Browse this author →KAKEN DB
Nakamura, Hideki Browse this author →KAKEN DB
Maya, Yuka Browse this author
Nishie, Wataru Browse this author →KAKEN DB
Kawada, Akira Browse this author →KAKEN DB
Shimizu, Hiroshi Browse this author →KAKEN DB
Keywords: epidermal nevus
nevus depigmentosus
melanosome
epidermal differentiation
keratin
filaggrin
Issue Date: Jan-2019
Publisher: John Libbey Eurotext
Journal Title: European journal of dermatology
Volume: 29
Issue: 1
Start Page: 45
End Page: 48
Publisher DOI: 10.1684/ejd.2018.3496
PMID: 30670370
Abstract: Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed. Objectives. To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Materials & Methods: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy. Results: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples. Conclusion: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.
Type: article (author version)
URI: http://hdl.handle.net/2115/74488
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 夏賀 健

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