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Congenital nevi with hypomelanosis and fine scales
| Title: | Congenital nevi with hypomelanosis and fine scales |
| Authors: | Natsuga, Ken Browse this author →KAKEN DB | | Oiso, Naoki Browse this author →KAKEN DB | | Kurokawa, Ichiro Browse this author | | Tsubura, Airo Browse this author →KAKEN DB | | Nakamura, Hideki Browse this author →KAKEN DB | | Maya, Yuka Browse this author | | Nishie, Wataru Browse this author →KAKEN DB | | Kawada, Akira Browse this author →KAKEN DB | | Shimizu, Hiroshi Browse this author →KAKEN DB |
| Keywords: | epidermal nevus | | nevus depigmentosus | | melanosome | | epidermal differentiation | | keratin | | filaggrin |
| Issue Date: | Jan-2019 |
| Publisher: | John Libbey Eurotext |
| Journal Title: | European journal of dermatology |
| Volume: | 29 |
| Issue: | 1 |
| Start Page: | 45 |
| End Page: | 48 |
| Publisher DOI: | 10.1684/ejd.2018.3496 |
| PMID: | 30670370 |
| Abstract: | Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed. Objectives. To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Materials & Methods: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy. Results: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples. Conclusion: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/74488 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 夏賀 健
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