| Title: | Clinical effectiveness of four neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan |
| Authors: | Ishiguro, Nobuhisa Browse this author →KAKEN DB |
| Koseki, Naoko Browse this author |
| Kaiho, Miki Browse this author |
| Ariga, Tadashi Browse this author →KAKEN DB |
| Kikuta, Hideaki Browse this author |
| Oba, Koji Browse this author →KAKEN DB |
| Togashi, Takehiro Browse this author |
| Morita, Keisuke Browse this author |
| Inagawa, Akira Browse this author |
| Okamura, Akiko Browse this author |
| Yamazaki, Shigeru Browse this author |
| Shida, Satoru Browse this author |
| Konno, Mutsuko Browse this author |
| Kawamura, Nobuaki Browse this author →KAKEN DB |
| Ishizaka, Akihito Browse this author |
| Takada, Kimihiko Browse this author |
| Tsubakihara, Keiji Browse this author |
| Nagano, Naoko Browse this author |
| Shibata, Mutsuo Browse this author |
| Furuyama, Hideto Browse this author |
| Matsuzono, Yoshihiro Browse this author |
| Koike, Akemi Browse this author |
| Murashita, Mari Browse this author |
| Hatae, Yoshio Browse this author |
| Arioka, Hideki Browse this author |
| Yamanaka, Tatsuru Browse this author |
| Watanabe, Toru Browse this author |
| Tabata, Yuuichi Browse this author |
| Kumita, Yoshihiro Browse this author |
| Hazama, Kyosuke Browse this author |
| Akutsu, Yasushi Browse this author |
| Aoyagi, Hayato Browse this author |
| Tobise, Chie Browse this author |
| Azuma, Katsuki Browse this author |
| Yasoshima, Kohichi Browse this author |
| Sawada, Yoko Browse this author |
| Uetsuji, Kazuyuki Browse this author |
| Tsuchida, Akira Browse this author |
| Tsuchiyama, Akira Browse this author |
| Yasuda, Kazue Browse this author |
| Odagawa, Yasuhisa Browse this author |
| Yoshioka, Mikio Browse this author |
| Keywords: | Oseltamivir |
| Zanamivir |
| Laninamivir |
| Peramivir |
| Influenza A |
| Influenza B |
| Issue Date: | Jun-2018 |
| Publisher: | Elsevier |
| Journal Title: | Journal of infection and chemotherapy |
| Volume: | 24 |
| Issue: | 6 |
| Start Page: | 449 |
| End Page: | 457 |
| Publisher DOI: | 10.1016/j.jiac.2018.01.013 |
| PMID: | 29487035 |
| Abstract: | The clinical effectiveness of four neuraminidase inhibitors (NAIs) (oseltamivir, zanamivir, laninamivir, and peramivir) for children aged 0 months to 18 years with influenza A and B were investigated in the 2014-2015 to 2016-2017 influenza seasons in Japan. A total of 1207 patients (747 with influenza A and 460 with influenza B) were enrolled. The Cox proportional-hazards model using all of the patients showed that the duration of fever after administration of the first dose of the NAI was shorter in older patients (hazard ratio = 1.06 per 1 year of age, p < 0.001) and that the duration of fever after administration of the first dose of the NAI was shorter in patients with influenza A infection than in patients with influenza B infection (hazard ratio = 2.21, p < 0.001). A logistic regression model showed that the number of biphasic fever episodes was 2.99-times greater for influenza B-infected patients than for influenza A-infected patients (p < 0.001). The number of biphasic fever episodes in influenza A-or B-infected patients aged 0-4 years was 2.89-times greater than that in patients aged 10-18 years (p = 0.010), and the number of episodes in influenza A-or B-infected patients aged 5-9 years was 2.13times greater than that in patients aged 10-18 years (p = 0.012). |
| Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/74500 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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