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Clinical effectiveness of four neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/74500

Title: Clinical effectiveness of four neuraminidase inhibitors (oseltamivir, zanamivir, laninamivir, and peramivir) for children with influenza A and B in the 2014-2015 to 2016-2017 influenza seasons in Japan
Authors: Ishiguro, Nobuhisa Browse this author →KAKEN DB
Koseki, Naoko Browse this author
Kaiho, Miki Browse this author
Ariga, Tadashi Browse this author →KAKEN DB
Kikuta, Hideaki Browse this author
Oba, Koji Browse this author →KAKEN DB
Togashi, Takehiro Browse this author
Morita, Keisuke Browse this author
Inagawa, Akira Browse this author
Okamura, Akiko Browse this author
Yamazaki, Shigeru Browse this author
Shida, Satoru Browse this author
Konno, Mutsuko Browse this author
Kawamura, Nobuaki Browse this author →KAKEN DB
Ishizaka, Akihito Browse this author
Takada, Kimihiko Browse this author
Tsubakihara, Keiji Browse this author
Nagano, Naoko Browse this author
Shibata, Mutsuo Browse this author
Furuyama, Hideto Browse this author
Matsuzono, Yoshihiro Browse this author
Koike, Akemi Browse this author
Murashita, Mari Browse this author
Hatae, Yoshio Browse this author
Arioka, Hideki Browse this author
Yamanaka, Tatsuru Browse this author
Watanabe, Toru Browse this author
Tabata, Yuuichi Browse this author
Kumita, Yoshihiro Browse this author
Hazama, Kyosuke Browse this author
Akutsu, Yasushi Browse this author
Aoyagi, Hayato Browse this author
Tobise, Chie Browse this author
Azuma, Katsuki Browse this author
Yasoshima, Kohichi Browse this author
Sawada, Yoko Browse this author
Uetsuji, Kazuyuki Browse this author
Tsuchida, Akira Browse this author
Tsuchiyama, Akira Browse this author
Yasuda, Kazue Browse this author
Odagawa, Yasuhisa Browse this author
Yoshioka, Mikio Browse this author
Keywords: Oseltamivir
Zanamivir
Laninamivir
Peramivir
Influenza A
Influenza B
Issue Date: Jun-2018
Publisher: Elsevier
Journal Title: Journal of infection and chemotherapy
Volume: 24
Issue: 6
Start Page: 449
End Page: 457
Publisher DOI: 10.1016/j.jiac.2018.01.013
PMID: 29487035
Abstract: The clinical effectiveness of four neuraminidase inhibitors (NAIs) (oseltamivir, zanamivir, laninamivir, and peramivir) for children aged 0 months to 18 years with influenza A and B were investigated in the 2014-2015 to 2016-2017 influenza seasons in Japan. A total of 1207 patients (747 with influenza A and 460 with influenza B) were enrolled. The Cox proportional-hazards model using all of the patients showed that the duration of fever after administration of the first dose of the NAI was shorter in older patients (hazard ratio = 1.06 per 1 year of age, p < 0.001) and that the duration of fever after administration of the first dose of the NAI was shorter in patients with influenza A infection than in patients with influenza B infection (hazard ratio = 2.21, p < 0.001). A logistic regression model showed that the number of biphasic fever episodes was 2.99-times greater for influenza B-infected patients than for influenza A-infected patients (p < 0.001). The number of biphasic fever episodes in influenza A-or B-infected patients aged 0-4 years was 2.89-times greater than that in patients aged 10-18 years (p = 0.010), and the number of episodes in influenza A-or B-infected patients aged 5-9 years was 2.13times greater than that in patients aged 10-18 years (p = 0.012).
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/74500
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石黒 信久

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