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Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation

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Title: Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation
Authors: Koganemaru, Satoko Browse this author
Mikami, Yusuke Browse this author
Maezawa, Hitoshi Browse this author →KAKEN DB
Ikeda, Satoshi Browse this author
Ikoma, Katsunori Browse this author →KAKEN DB
Mima, Tatsuya Browse this author →KAKEN DB
Keywords: learning
GABAergic neuron
intracortical inhibition
transcranial magnetic stimulation
Issue Date: 1-Jun-2018
Publisher: Elsevier
Journal Title: Neuroscience
Volume: 380
Start Page: 38
End Page: 48
Publisher DOI: 10.1016/j.neuroscience.2018.03.051
PMID: 29649513
Abstract: Neurofeedback has been a powerful method for self-regulating brain activities to elicit potential ability of human mind. GABA is a major inhibitory neurotransmitter in the central nervous system. Transcranial magnetic stimulation (TMS) is a tool that can evaluate the GABAergic system within the primary motor cortex (M1) using paired-pulse stimuli, short intracortical inhibition (SICI). Herein we investigated whether neurofeedback learning using SICI enabled us to control the GABAergic system within the M1 area. Forty-five healthy subjects were randomly divided into two groups: those receiving SICI neurofeedback learning or those receiving no neurofeedback (control) learning. During both learning periods, subjects made attempts to change the size of a circle, which was altered according to the degree of SICI in the SICI neurofeedback learning group, and which was altered independent of the degree of SICI in the control learning group. Results demonstrated that the SICI neurofeedback learning group showed a significant enhancement in SICI. Moreover, this group showed a significant reduction in choice reaction time compared to the control group. Our findings indicate that humans can intrinsically control the intracortical GABAergic system within M1 and can thus improve motor behaviors by SICI neurofeedback learning. SICI neurofeedback learning is a novel and promising approach to control our neural system and potentially represents a new therapy for patients with abnormal motor symptoms caused by CNS disorders.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小金丸 聡子

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