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Historical aspects of studies on roles of the inflammasome in the pathogenesis of periodontal diseases

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Title: Historical aspects of studies on roles of the inflammasome in the pathogenesis of periodontal diseases
Authors: Shibata, Ken-ichiro Browse this author →KAKEN DB
Keywords: inflammasome
periodontal disease
Porphyromonas gingivalis
Issue Date: Jun-2018
Publisher: Wiley
Journal Title: Molecular Oral Microbiology
Volume: 33
Issue: 3
Start Page: 203
End Page: 221
Publisher DOI: 10.1111/omi.12217
PMID: 29360244
Abstract: The proinflammatory cytokine interleukin-1β(IL-1β) is produced as inactive proIL-1β and then processed by caspase-1 to become active. In 2002, it was demonstrated that the intracellular multiprotein complex known as the inflammasome functions as a molecular platform to trigger activation of caspase-1. Inflammasomes are known to function as intracellular sensors for a broad spectrum of various pathogen-associated and damage-associated molecular patterns. In 1985, it was demonstrated that Porphyromonas gingivalis, a representative bacterium causing chronic periodontitis, induces IL-1 production by murine peritoneal macrophages. Since then, many studies have suggested that IL-1, particularly IL-1β plays key roles in the pathogenesis of periodontal diseases. However, the term “inflammasome” was not used until the involvement of inflammasomes in periodontal disease was suggested in 2009. Several subsequent studies on the roles of the inflammasome in the pathogenesis of periodontal diseases have been published. Interestingly, two contradictory reports on the modulation of inflammasomes by P. gingivalis have been published. Some papers have described how P. gingivalis activates the inflammasome to produce IL-1β whereas some stated that P. gingivalis inhibits inflammasome activation to subvert immune responses. Several lines of evidence have suggested that the inflammasome activation is modulated by periodontopathic bacteria other than P. gingivalis. Hence, studies on the roles of inflammasomes in the pathogenesis of periodontal diseases began only 8 years ago and many pathological roles of inflammasomes remain to be clarified.
Rights: This is the peer reviewed version of the following article: Historical aspects of studies on roles of the inflammasome in the pathogenesis of periodontal diseases, which has been published in final form at https://doi.org/10.1111/omi.12217. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Type: article (author version)
URI: http://hdl.handle.net/2115/74519
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柴田 健一郎

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