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A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates
| Title: | A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates |
| Authors: | Kojima, Ryoto Browse this author | | Akiyama, Sota Browse this author | | Ito, Hajime Browse this author →KAKEN DB |
| Keywords: | asymmetric catalysis | | boron | | copper | | fluorine | | synthetic methods |
| Issue Date: | 11-Jun-2018 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Angewandte chemie-international edition |
| Volume: | 57 |
| Issue: | 24 |
| Start Page: | 7196 |
| End Page: | 7199 |
| Publisher DOI: | 10.1002/anie.201803663 |
| Abstract: | The first catalytic enantioselective -boryl substitution of CF3-substituted alkenes is reported. A series of CF3-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the corresponding optically active ,-gem-difluoroallylboronates in high enantioselectivity. The thus obtained products could be readily converted into the corresponding difluoromethylene-containing homoallylic alcohols using highly stereospecific allylation reactions. |
| Rights: | This is the peer reviewed version of the following article: Angewandte chemie-international edition 57 (24) pp.7196-7199 2018-06-11, which has been published in final form at https://doi.org/10.1002/anie.201803663. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/74598 |
| Appears in Collections: | 総合化学院 (Graduate School of Chemical Sciences and Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 秋山 颯太
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