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A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates

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Title: A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates
Authors: Kojima, Ryoto Browse this author
Akiyama, Sota Browse this author
Ito, Hajime Browse this author →KAKEN DB
Keywords: asymmetric catalysis
boron
copper
fluorine
synthetic methods
Issue Date: 11-Jun-2018
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie-international edition
Volume: 57
Issue: 24
Start Page: 7196
End Page: 7199
Publisher DOI: 10.1002/anie.201803663
Abstract: The first catalytic enantioselective -boryl substitution of CF3-substituted alkenes is reported. A series of CF3-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the corresponding optically active ,-gem-difluoroallylboronates in high enantioselectivity. The thus obtained products could be readily converted into the corresponding difluoromethylene-containing homoallylic alcohols using highly stereospecific allylation reactions.
Rights: This is the peer reviewed version of the following article: Angewandte chemie-international edition 57 (24) pp.7196-7199 2018-06-11, which has been published in final form at https://doi.org/10.1002/anie.201803663. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/74598
Appears in Collections:総合化学院 (Graduate School of Chemical Sciences and Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 秋山 颯太

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