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A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates
Title: | A Copper(I)-Catalyzed Enantioselective -Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched gamma,gamma-gem-Difluoroallylboronates |
Authors: | Kojima, Ryoto Browse this author | Akiyama, Sota Browse this author | Ito, Hajime Browse this author →KAKEN DB |
Keywords: | asymmetric catalysis | boron | copper | fluorine | synthetic methods |
Issue Date: | 11-Jun-2018 |
Publisher: | Wiley-Blackwell |
Journal Title: | Angewandte chemie-international edition |
Volume: | 57 |
Issue: | 24 |
Start Page: | 7196 |
End Page: | 7199 |
Publisher DOI: | 10.1002/anie.201803663 |
Abstract: | The first catalytic enantioselective -boryl substitution of CF3-substituted alkenes is reported. A series of CF3-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the corresponding optically active ,-gem-difluoroallylboronates in high enantioselectivity. The thus obtained products could be readily converted into the corresponding difluoromethylene-containing homoallylic alcohols using highly stereospecific allylation reactions. |
Rights: | This is the peer reviewed version of the following article: Angewandte chemie-international edition 57 (24) pp.7196-7199 2018-06-11, which has been published in final form at https://doi.org/10.1002/anie.201803663. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/74598 |
Appears in Collections: | 総合化学院 (Graduate School of Chemical Sciences and Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 秋山 颯太
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