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Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/74824

Title: Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma
Authors: Konishi, Yuji Browse this author
Kawamata, Futoshi Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Homma, Shigenori Browse this author →KAKEN DB
Kato, Yasutaka Browse this author
Tsuda, Masumi Browse this author →KAKEN DB
Kohsaka, Shinji Browse this author
Einama, Takahiro Browse this author
Liu, Cheng Browse this author
Yoshida, Tadashi Browse this author →KAKEN DB
Nagatsu, Akihisa Browse this author
Tanino, Mishie Browse this author →KAKEN DB
Tanaka, Shinya Browse this author →KAKEN DB
Kawamura, Hideki Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Keywords: Tumor budding
Human chorionic gonadotropin
Colorectal cancer
Epithelial-to-mesenchymal transition
Prognostic factor
Issue Date: Jul-2018
Publisher: Springer
Journal Title: Medical oncology
Volume: 35
Issue: 7
Start Page: 104
Publisher DOI: 10.1007/s12032-018-1164-x
PMID: 29892782
Abstract: Tumor budding is thought to represent a manifestation of epithelial-to-mesenchymal transition (EMT) and it has been correlated with poor patient outcomes in colorectal cancer (CRC). Our group recently demonstrated that human chorionic gonadotropin-β (hCGβ) modulates EMT in CRC. In the current study, based on the likely relationships between tumor budding and hCGβ expression, we examined their clinicopathologic significance in CRC. Twenty-eight of 80 (35.0%) CRC showed tumor budding. Tumor budding significantly correlated with lymph node metastasis (P < 0.01), pathologic stage (P < 0.01), lymphatic invasion (P = 0.044), and vascular invasion (P = 0.013). Thirteen of 80 (16.3%) CRC were hCGβ positive on immunohistochemistry. More tumor buds were present in the hCGβ-positive cases (P < 0.01), and tumor budding was significantly correlated with hCGβ positivity (P < 0.01). Cases with both tumor budding and hCGβ expression had the poorest prognosis compared with all other groups (P < 0.01). In conclusion, tumor budding and hCGβ expression are closely associated with EMT, and they are independent prognostic factors in CRC. They identify patients with an "EMT phenotype" who may respond to targeted molecular therapies.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/74824
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川俣 太

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