Title: | Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma |
Authors: | Konishi, Yuji Browse this author |
Kawamata, Futoshi Browse this author |
Nishihara, Hiroshi Browse this author →KAKEN DB |
Homma, Shigenori Browse this author →KAKEN DB |
Kato, Yasutaka Browse this author |
Tsuda, Masumi Browse this author →KAKEN DB |
Kohsaka, Shinji Browse this author |
Einama, Takahiro Browse this author |
Liu, Cheng Browse this author |
Yoshida, Tadashi Browse this author →KAKEN DB |
Nagatsu, Akihisa Browse this author |
Tanino, Mishie Browse this author →KAKEN DB |
Tanaka, Shinya Browse this author →KAKEN DB |
Kawamura, Hideki Browse this author →KAKEN DB |
Kamiyama, Toshiya Browse this author →KAKEN DB |
Taketomi, Akinobu Browse this author →KAKEN DB |
Keywords: | Tumor budding |
Human chorionic gonadotropin |
Colorectal cancer |
Epithelial-to-mesenchymal transition |
Prognostic factor |
Issue Date: | Jul-2018 |
Publisher: | Springer |
Journal Title: | Medical oncology |
Volume: | 35 |
Issue: | 7 |
Start Page: | 104 |
Publisher DOI: | 10.1007/s12032-018-1164-x |
PMID: | 29892782 |
Abstract: | Tumor budding is thought to represent a manifestation of epithelial-to-mesenchymal transition (EMT) and it has been correlated with poor patient outcomes in colorectal cancer (CRC). Our group recently demonstrated that human chorionic gonadotropin-β (hCGβ) modulates EMT in CRC. In the current study, based on the likely relationships between tumor budding and hCGβ expression, we examined their clinicopathologic significance in CRC. Twenty-eight of 80 (35.0%) CRC showed tumor budding. Tumor budding significantly correlated with lymph node metastasis (P < 0.01), pathologic stage (P < 0.01), lymphatic invasion (P = 0.044), and vascular invasion (P = 0.013). Thirteen of 80 (16.3%) CRC were hCGβ positive on immunohistochemistry. More tumor buds were present in the hCGβ-positive cases (P < 0.01), and tumor budding was significantly correlated with hCGβ positivity (P < 0.01). Cases with both tumor budding and hCGβ expression had the poorest prognosis compared with all other groups (P < 0.01). In conclusion, tumor budding and hCGβ expression are closely associated with EMT, and they are independent prognostic factors in CRC. They identify patients with an "EMT phenotype" who may respond to targeted molecular therapies. |
Rights: | The final publication is available at link.springer.com |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/74824 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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