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Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment
| Title: | Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment |
| Authors: | Asano, Toshimichi Browse this author →KAKEN DB | | Hirano, Satoshi Browse this author →KAKEN DB | | Nakamura, Toru Browse this author →KAKEN DB | | Okamura, Keisuke Browse this author →KAKEN DB | | Tsuchikawa, Takahiro Browse this author →KAKEN DB | | Noji, Takehiro Browse this author →KAKEN DB | | Nakanishi, Yoshitsugu Browse this author →KAKEN DB | | Tanaka, Kimitaka Browse this author →KAKEN DB | | Shichinohe, Toshiaki Browse this author →KAKEN DB |
| Keywords: | Conversion surgery | | Multidisciplinary treatment | | Prognosis | | Survival analysis | | Unresectable pancreatic cancer |
| Issue Date: | Jul-2018 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of hepato-biliary-pancreatic sciences |
| Volume: | 25 |
| Issue: | 7 |
| Start Page: | 342 |
| End Page: | 350 |
| Publisher DOI: | 10.1002/jhbp.565 |
| PMID: | 29797499 |
| Abstract: | Background: Conversion surgery (CS) is expected as a new therapeutic strategy for patients with unresectable pancreatic cancer (UR-PC). We analyzed outcomes of CS for patients with UR-PC and evaluated the survival benefit of CS. Methods: Thirty-four patients diagnosed with UR-PC according to the National Comprehensive Cancer Network guideline underwent CS in our hospital. Resectability was considered by multimodal images in patients who underwent nonsurgical treatment (NST) for more than 6 months. CS was performed only in patients who were judged to be able to undergo R0 resection. Results: Twenty-six patients had locally advanced PC, and eight had distant metastases. The median duration of NST was 9 (range 5-44) months. R0 resection was achieved in 30 patients (88.2%). Six patients (17.6%) showed Evans grade ≥III. Three- and 5-year overall survival (OS) rates from initial treatment were 74% and 56.9%, respectively, with median survival time (MST) of 5.3 years. The actual 5-year OS rate in 19 patients was 47.4% with an MST of 4.0 years. Patients with Evans grade ≥III had a better prognosis than those with Evans grade <III (P = 0.0092, log-rank test). Conclusions: Conversion surgery might have survival benefits to patients with UR-PC who responded favorably to NST. |
| Rights: | This is the peer reviewed version of the following article: Asano, T., Hirano, S., Nakamura, T., Okamura, K., Tsuchikawa, T., Noji, T., Nakanishi, Y., Tanaka, K. and Shichinohe, T. (2018), Survival benefit of conversion surgery for patients with initially unresectable pancreatic cancer who responded favorably to nonsurgical treatment. J Hepatobiliary Pancreat Sci, 25: 342-350., which has been published in final form at https://doi.org/10.1002/jhbp.565. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/74831 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 浅野 賢道
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