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The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus

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Title: The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus
Authors: Niwa, Hirokatsu Browse this author
Takahashi, Kiyohiko Browse this author
Dannoura, Midori Browse this author
Oomori, Kazuno Browse this author
Miyoshi, Arina Browse this author
Inada, Toshihiro Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Keywords: Ankle-brachial pressure index
Cardio-ankle vascular index
Issue Date: 1-Jul-2019
Publisher: Japan Atherosclerosis Society
Journal Title: Journal of Atherosclerosis and Thrombosis
Volume: 26
Issue: 7
Start Page: 616
End Page: 623
Publisher DOI: 10.5551/jat.45674
PMID: 30487347
Abstract: Aims: This study elucidates the association of macroangiopathy development in type 2 diabetes patients with various arteriosclerosis risk factors (ARFs) and results of cardio-ankle vascular index (CAVI) and ankle-brachial pressure index (ABI).Methods: The correlation between current and past macroangiopathy development, with ARFs or CAVI/ABI data, was retrospectively analyzed using multivariate logistic regression in 816 patients with type 2 diabetes at a single center. C-statistics combining some independent variables selected using the stepwise method were evaluated.Results: CAVI was significantly correlated with microangiopathies, including coronary artery disease (CAD), arteriosclerosis obliterans (ASO), and stroke with odds ratios (OR) of 1.20, 1.22, and 1.19, respectively. ABI significantly correlated with ASO and stroke with respective OR of 13.6 and 2.47, but not with CAD. Areas under the receiver operating characteristic curves (ROCs) revealed the accuracy of detecting ASO and stroke was increased by the combination of CAVI+ABI (0.94 and 0.74, respectively). However, areas under the ROC for the presence of CAD can be increased by the combination of CAVI and ARFs especially including dyslipidemia.Conclusion: CAVI/ABI and some ARFs are useful tools in daily clinical care units to identify the current and past existence of macroangiopathy in patients with type 2 diabetes, but the prediction weights using these factors were different among CAD, ASO, and stroke.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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