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Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial -

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Title: Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial -
Authors: Tsutsui, Hiroyuki Browse this author →KAKEN DB
Momomura, Shin-ichi Browse this author →KAKEN DB
Masuyama, Tohru Browse this author →KAKEN DB
Saito, Yoshihiko Browse this author →KAKEN DB
Komuro, Issei Browse this author →KAKEN DB
Murohara, Toyoaki Browse this author →KAKEN DB
Kinugawa, Shintaro Browse this author →KAKEN DB
Oba, Koji Browse this author
Sato, Norihiro Browse this author
Yasumura, Yoshio Browse this author
Hiramitsu, Shinya Browse this author
Satou, Yukihito Browse this author
Inomata, Takayuki Browse this author
Onishi, Katsuya Browse this author
Sakata, Yasushi Browse this author
Mizuno, Kyoichi Browse this author
Sunagawa, Kenji Browse this author
Ogawa, Hisao Browse this author
Isobe, Mitsuaki Browse this author
Daida, Hiroyuki Browse this author
Kurabayashi, Masahiko Browse this author
Kinugawa, Shintaro Browse this author
Kohya, Tetsuro Browse this author
Ogawa, Yuji Browse this author
Itoh, Naofumi Browse this author
Kakinoki, Shigeo Browse this author
Aoki, Kenji Browse this author
Tsuchida, Akihito Browse this author
Ito, Hiroshi Browse this author
Yamaguchi, Osamu Browse this author
Eki, Yutaka Browse this author
Toyoda, Shigeru Browse this author
Nakano, Akihiko Browse this author
Koitabashi, Norimichi Browse this author
Muramatsu, Toshihiro Browse this author
Nakahara, Hideo Browse this author
Tanaka, Hiroyuki Browse this author
Yamashina, Akira Browse this author
Takasu, Kiyoshi Browse this author
Maejima, Yasuhiro Browse this author
Momiyama, Yukihiko Browse this author
Nakamura, Iwao Browse this author
Kida, Keisuke Browse this author
Naruke, Takashi Browse this author
Takenobu, Hideshi Browse this author
Minamino, Tohru Browse this author
Nakamura, Masahiko Browse this author
Ikeda, Masatoshi Browse this author
Ashida, Kazuhiro Browse this author
Takahashi, Shigekiyo Browse this author
Minatoguchi, Shinya Browse this author
Suwa, Satoru Browse this author
Satoh, Hiroshi Browse this author
Izawa, Hideo Browse this author
Fukuta, Hidekatsu Browse this author
Tsuboi, Naoya Browse this author
Uzui, Hiroyasu Browse this author
Wada, Atsuyuki Browse this author
Kimura, Takeshi Browse this author
Takenaka, Ken Browse this author
Kato, Takao Browse this author
Okutsu, Masaaki Browse this author
Ohtani, Tomohito Browse this author
Hasegawa, Shinji Browse this author
Anzai, Toshihisa Browse this author
Fujii, Kenshi Browse this author
Shiojima, Ichiro Browse this author
Yasaka, Yoshinori Browse this author
Masuyama, Tohru Browse this author
Hirata, Ken-ichi Browse this author
Saito, Yoshihiko Browse this author
Akasaka, Takashi Browse this author
Ito, Hiroshi Browse this author
Kihara, Yasuki Browse this author
Tamura, Ritsu Browse this author
Teragawa, Hiroki Browse this author
Yasuda, Kotaro Browse this author
Okuhara, Koichiro Browse this author
Karashima, Eiji Browse this author
Sata, Masataka Browse this author
Ota, Akira Browse this author
Noma, Takahisa Browse this author
Suzuki, Jun Browse this author
Watanabe, Kouki Browse this author
Kitaoka, Hiroaki Browse this author
Matsukawa, Ryuichi Browse this author
Yoshihiro, Takeshi Browse this author
Tanaka, Nobuhide Browse this author
Ozumi, Kiyoshi Browse this author
Takahashi, Masaru Browse this author
Maemura, Koji Browse this author
Atsuchi, Nobuhiko Browse this author
Keywords: beta-blocker
Bisoprolol
Carvedilol
Heart failure
Tolerability
Issue Date: Jun-2019
Publisher: 社団法人 日本循環器学会(The Japanese Circulation Society)JCS
Journal Title: Circulation journal
Volume: 83
Issue: 6
Start Page: 1269
End Page: 1277
Publisher DOI: 10.1253/circj.CJ-18-1199
PMID: 30956267
Abstract: Background: The comparative tolerability, efficacy, and safety of bisoprolol and carvedilol have not been established in Japanese patients with heart failure and reduced ejection fraction (HFrEF). Methods and Results: The CIBIS-J trial is a multicenter, open-label, non-inferiority randomized controlled trial of bisoprolol vs. carvedilol in 217 patients with HFrEF (EF <= 40%). The primary endpoint was tolerability, defined as reaching and maintaining the maximum maintenance dose (bisoprolol 5 mg/day or carvedilol 20 mg/day) during 48 weeks of treatment. The primary endpoint was achieved in 41.4% of patients in bisoprolol (n=111) and 42.5% in carvedilol (n=106) groups. The non-inferiority of tolerability of bisoprolol compared with carvedilol was not supported, however, neither beta-blocker was superior with regard to tolerability. Heart rate (HR) decreased in both groups and its decrease from baseline was significantly greater in the bisoprolol group (20.3 vs. 15.4 beats/min at 24 week, P<0.05). Plasma B-type natriuretic peptide (BNP) levels decreased in both groups and the decrease was significantly greater in the carvedilol group (12.4 vs. 39.0 % at 24 weeks, P<0.05). Conclusions: There were no significant differences between bisoprolol and carvedilol in the tolerability of target doses in Japanese HFrEF patients. The clinical efficacy and safety were also similar despite the greater reduction in HR by bisoprolol and plasma BNP by carvedilol.
Type: article
URI: http://hdl.handle.net/2115/75006
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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