Title: | Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial - |
Authors: | Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Momomura, Shin-ichi Browse this author →KAKEN DB |
Masuyama, Tohru Browse this author →KAKEN DB |
Saito, Yoshihiko Browse this author →KAKEN DB |
Komuro, Issei Browse this author →KAKEN DB |
Murohara, Toyoaki Browse this author →KAKEN DB |
Kinugawa, Shintaro Browse this author →KAKEN DB |
Oba, Koji Browse this author |
Sato, Norihiro Browse this author |
Yasumura, Yoshio Browse this author |
Hiramitsu, Shinya Browse this author |
Satou, Yukihito Browse this author |
Inomata, Takayuki Browse this author |
Onishi, Katsuya Browse this author |
Sakata, Yasushi Browse this author |
Mizuno, Kyoichi Browse this author |
Sunagawa, Kenji Browse this author |
Ogawa, Hisao Browse this author |
Isobe, Mitsuaki Browse this author |
Daida, Hiroyuki Browse this author |
Kurabayashi, Masahiko Browse this author |
Kinugawa, Shintaro Browse this author |
Kohya, Tetsuro Browse this author |
Ogawa, Yuji Browse this author |
Itoh, Naofumi Browse this author |
Kakinoki, Shigeo Browse this author |
Aoki, Kenji Browse this author |
Tsuchida, Akihito Browse this author |
Ito, Hiroshi Browse this author |
Yamaguchi, Osamu Browse this author |
Eki, Yutaka Browse this author |
Toyoda, Shigeru Browse this author |
Nakano, Akihiko Browse this author |
Koitabashi, Norimichi Browse this author |
Muramatsu, Toshihiro Browse this author |
Nakahara, Hideo Browse this author |
Tanaka, Hiroyuki Browse this author |
Yamashina, Akira Browse this author |
Takasu, Kiyoshi Browse this author |
Maejima, Yasuhiro Browse this author |
Momiyama, Yukihiko Browse this author |
Nakamura, Iwao Browse this author |
Kida, Keisuke Browse this author |
Naruke, Takashi Browse this author |
Takenobu, Hideshi Browse this author |
Minamino, Tohru Browse this author |
Nakamura, Masahiko Browse this author |
Ikeda, Masatoshi Browse this author |
Ashida, Kazuhiro Browse this author |
Takahashi, Shigekiyo Browse this author |
Minatoguchi, Shinya Browse this author |
Suwa, Satoru Browse this author |
Satoh, Hiroshi Browse this author |
Izawa, Hideo Browse this author |
Fukuta, Hidekatsu Browse this author |
Tsuboi, Naoya Browse this author |
Uzui, Hiroyasu Browse this author |
Wada, Atsuyuki Browse this author |
Kimura, Takeshi Browse this author |
Takenaka, Ken Browse this author |
Kato, Takao Browse this author |
Okutsu, Masaaki Browse this author |
Ohtani, Tomohito Browse this author |
Hasegawa, Shinji Browse this author |
Anzai, Toshihisa Browse this author |
Fujii, Kenshi Browse this author |
Shiojima, Ichiro Browse this author |
Yasaka, Yoshinori Browse this author |
Masuyama, Tohru Browse this author |
Hirata, Ken-ichi Browse this author |
Saito, Yoshihiko Browse this author |
Akasaka, Takashi Browse this author |
Ito, Hiroshi Browse this author |
Kihara, Yasuki Browse this author |
Tamura, Ritsu Browse this author |
Teragawa, Hiroki Browse this author |
Yasuda, Kotaro Browse this author |
Okuhara, Koichiro Browse this author |
Karashima, Eiji Browse this author |
Sata, Masataka Browse this author |
Ota, Akira Browse this author |
Noma, Takahisa Browse this author |
Suzuki, Jun Browse this author |
Watanabe, Kouki Browse this author |
Kitaoka, Hiroaki Browse this author |
Matsukawa, Ryuichi Browse this author |
Yoshihiro, Takeshi Browse this author |
Tanaka, Nobuhide Browse this author |
Ozumi, Kiyoshi Browse this author |
Takahashi, Masaru Browse this author |
Maemura, Koji Browse this author |
Atsuchi, Nobuhiko Browse this author |
Keywords: | beta-blocker |
Bisoprolol |
Carvedilol |
Heart failure |
Tolerability |
Issue Date: | Jun-2019 |
Publisher: | The Japanese Circulation Society |
Journal Title: | Circulation journal |
Volume: | 83 |
Issue: | 6 |
Start Page: | 1269 |
End Page: | 1277 |
Publisher DOI: | 10.1253/circj.CJ-18-1199 |
PMID: | 30956267 |
Abstract: | Background: The comparative tolerability, efficacy, and safety of bisoprolol and carvedilol have not been established in Japanese patients with heart failure and reduced ejection fraction (HFrEF). Methods and Results: The CIBIS-J trial is a multicenter, open-label, non-inferiority randomized controlled trial of bisoprolol vs. carvedilol in 217 patients with HFrEF (EF <= 40%). The primary endpoint was tolerability, defined as reaching and maintaining the maximum maintenance dose (bisoprolol 5 mg/day or carvedilol 20 mg/day) during 48 weeks of treatment. The primary endpoint was achieved in 41.4% of patients in bisoprolol (n=111) and 42.5% in carvedilol (n=106) groups. The non-inferiority of tolerability of bisoprolol compared with carvedilol was not supported, however, neither beta-blocker was superior with regard to tolerability. Heart rate (HR) decreased in both groups and its decrease from baseline was significantly greater in the bisoprolol group (20.3 vs. 15.4 beats/min at 24 week, P<0.05). Plasma B-type natriuretic peptide (BNP) levels decreased in both groups and the decrease was significantly greater in the carvedilol group (12.4 vs. 39.0 % at 24 weeks, P<0.05). Conclusions: There were no significant differences between bisoprolol and carvedilol in the tolerability of target doses in Japanese HFrEF patients. The clinical efficacy and safety were also similar despite the greater reduction in HR by bisoprolol and plasma BNP by carvedilol. |
Type: | article |
URI: | http://hdl.handle.net/2115/75006 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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