|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells |
| Authors: | Horinouchi, Takahiro Browse this author →KAKEN DB | | Karki, Sarita Browse this author | | Terada, Koji Browse this author →KAKEN DB | | Mazaki, Yuichi Browse this author | | Miwa, Soichi Browse this author →KAKEN DB |
| Keywords: | Endothelin type A receptor | | Internalization | | Ca2+ signal |
| Issue Date: | May-2019 |
| Publisher: | Japanese Pharmacological Society |
| Journal Title: | Journal of pharmacological sciences |
| Volume: | 140 |
| Issue: | 1 |
| Start Page: | 102 |
| End Page: | 105 |
| Publisher DOI: | 10.1016/j.jphs.2019.03.008 |
| PMID: | 31103330 |
| Abstract: | Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracellular Ca2+ concentration. ET-1-induced ETAR internalization was completely inhibited by a reduction in intracellular and extracellular Ca2+ levels and partially suppressed by inhibitors of protein kinase C (PKC) and extracellular signal-regulated kinases 1/2 (ERK1/2), both of which are downstream molecules in ETAR signaling. These results suggest that Ca2+ mobilization, PKC, and ERK1/2 are involved in ET-1-induced ETAR internalization. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75009 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
