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Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells

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Title: Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells
Authors: Horinouchi, Takahiro Browse this author →KAKEN DB
Karki, Sarita Browse this author
Terada, Koji Browse this author →KAKEN DB
Mazaki, Yuichi Browse this author
Miwa, Soichi Browse this author →KAKEN DB
Keywords: Endothelin type A receptor
Internalization
Ca2+ signal
Issue Date: May-2019
Publisher: Japanese Pharmacological Society
Journal Title: Journal of pharmacological sciences
Volume: 140
Issue: 1
Start Page: 102
End Page: 105
Publisher DOI: 10.1016/j.jphs.2019.03.008
PMID: 31103330
Abstract: Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracellular Ca2+ concentration. ET-1-induced ETAR internalization was completely inhibited by a reduction in intracellular and extracellular Ca2+ levels and partially suppressed by inhibitors of protein kinase C (PKC) and extracellular signal-regulated kinases 1/2 (ERK1/2), both of which are downstream molecules in ETAR signaling. These results suggest that Ca2+ mobilization, PKC, and ERK1/2 are involved in ET-1-induced ETAR internalization. (C) 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/75009
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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