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Detection of Fine Radiographic Progression in Finger Joint Space Narrowing Beyond Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis Patients
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| Title: | Detection of Fine Radiographic Progression in Finger Joint Space Narrowing Beyond Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis Patients |
| Authors: | Kato, Kazuki Browse this author | | Yasojima, Nobutoshi Browse this author | | Tamura, Kenichi Browse this author | | Ichikawa, Shota Browse this author | | Sutherland, Kenneth Browse this author →KAKEN DB | | Kato, Masaru Browse this author →KAKEN DB | | Fukae, Jun Browse this author | | Tanimura, Kazuhide Browse this author | | Tanaka, Yuki Browse this author →KAKEN DB | | Okino, Taichi Browse this author | | Lu, Yutong Browse this author | | Kamishima, Tamotsu Browse this author →KAKEN DB |
| Issue Date: | 12-Jun-2019 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 9 |
| Start Page: | 8526 |
| Publisher DOI: | 10.1038/s41598-019-44747-6 |
| Abstract: | The visual assessment of joint space narrowing (JSN) on radiographs of rheumatoid arthritis (RA) patients such as the Genant-modified Sharp score (GSS) is widely accepted but limited by its subjectivity and insufficient sensitivity. We developed a software application which can assess JSN quantitatively using a temporal subtraction technique for radiographs, in which the chronological change in JSN between two radiographs was defined as the joint space difference index (JSDI). The aim of this study is to prove the superiority of the software in terms of detecting fine radiographic progression in finger JSN over human observers. A micrometer measurement apparatus that can adjust arbitrary joint space width (JSW) in a phantom joint was developed to define true JSW. We compared the smallest detectable changes in JSW between the JSDI and visual assessment using phantom images. In a clinical study, 222 finger joints without interval score change on GSS in 15 RA patients were examined. We compared the JSDI between joints with and without synovial vascularity (SV) on power Doppler ultrasonography during the follow-up period. True JSW difference was correlated with JSDI for JSW differences ranging from 0.10 to 1.00 mm at increments of 0.10 mm (R-2 = 0.986 and P < 0.001). Rheumatologists were difficult to detect JSW difference of 0.30 mm or less. The JSDI of finger joints with SV was significantly higher than those without SV (P = 0.030). The software can detect fine differences in JSW that are visually unrecognizable. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/75011 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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