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Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status

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Title: Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status
Authors: Fujiwara-Kuroda, Aki Browse this author
Kato, Tatsuya Browse this author
Abiko, Takehiro Browse this author
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Kyogoku, Noriaki Browse this author
Ichinokawa, Masaomi Browse this author
Tanaka, Kimitaka Browse this author
Noji, Takehiro Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author →KAKEN DB
Kaga, Kichizo Browse this author →KAKEN DB
Matsui, Yoshiro Browse this author →KAKEN DB
Ikeda, Hiroaki Browse this author →KAKEN DB
Kageyama, Shinichi Browse this author →KAKEN DB
Shiku, Hiroshi Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: melanoma antigen family A4
non-small cell lung cancer
subcellular localization
tissue microarray
Issue Date: Aug-2018
Publisher: Spandidos Publications
Journal Title: International journal of oncology
Volume: 53
Issue: 2
Start Page: 713
End Page: 724
Publisher DOI: 10.3892/ijo.2018.4425
PMID: 29901069
Abstract: Melanoma antigen family A4 (MAGEA4), a cancer/testis antigen, is overexpressed and is thus an immunotherapy target in various malignant tumors, including non-small cell lung cancer. However, whether MAGEA4 induces or inhibits the apoptosis of lung cancer cells remains controversial, as is its prognostic significance, particularly since there is no reliable method with which to detect MAGEA4 specifically. In this study, we optimized assay conditions to detect MAGEA4 based on cells transiently transfected with MAGEA genes, and found that MAGEA4 was expressed in four of eight non-small cell lung cancer cell lines, and in 25.4% of clinical lung cancer specimens. We also found that MAGEA4 overexpression decreased apoptosis, as measured by the levels of cleaved caspase-3 in stably transfected 293F cells. Notably, patients with nuclear MAGEA4, but not p53 expression exhibited a significantly poorer survival than those expressing both nuclear MAGEA4 and p53. Indeed, multivariate analysis identified nuclear MAGEA4 as an independent prognostic factor (P=0.0042), albeit only in the absence of p53. In this study, to the best of our knowledge, we are the first to demonstrate that the function and prognostic value of MAGEA4 depends on its subcellular localization and on the p53 status.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 達哉

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