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Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase
| Title: | Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase |
| Authors: | Takayama, Risa Browse this author | | Hayakawa, Shun Browse this author | | Hinou, Hiroshi Browse this author →KAKEN DB | | Albericio, Fernando Browse this author | | Garcia-Martin, Fayna Browse this author →KAKEN DB |
| Keywords: | solid-phase synthesis | | esterification | | microwave irradiation | | depsipeptide |
| Issue Date: | Aug-2018 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of peptide science |
| Volume: | 24 |
| Issue: | 8-9 |
| Start Page: | UNSP e3111 |
| Publisher DOI: | 10.1002/psc.3111 |
| PMID: | 30009478 |
| Abstract: | Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid-phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid-phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization. |
| Rights: | This is the peer reviewed version of the following article: Journal of Peptide Science Volume24, Issue8-9, August-September 2018, e3111, which has been published in final form at https://doi.org/10.1002/psc.3111 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/75071 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: Garcia-Martin, Fayna Maria
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