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Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/75071

Title: Further applications of classical amide coupling reagents: Microwave-assisted esterification on solid phase
Authors: Takayama, Risa Browse this author
Hayakawa, Shun Browse this author
Hinou, Hiroshi Browse this author →KAKEN DB
Albericio, Fernando Browse this author
Garcia-Martin, Fayna Browse this author →KAKEN DB
Keywords: solid-phase synthesis
esterification
microwave irradiation
depsipeptide
Issue Date: Aug-2018
Publisher: John Wiley & Sons
Journal Title: Journal of peptide science
Volume: 24
Issue: 8-9
Start Page: UNSP e3111
Publisher DOI: 10.1002/psc.3111
PMID: 30009478
Abstract: Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid-phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid-phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization.
Rights: This is the peer reviewed version of the following article: Journal of Peptide Science Volume24, Issue8-9, August-September 2018, e3111, which has been published in final form at https://doi.org/10.1002/psc.3111 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/75071
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: Garcia-Martin, Fayna Maria

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